Cronkhite–Canada Syndrome: From Clinical Features to Treatment

Cronkhite–Canada syndrome (CCS) is a rare disorder with over 500 cases reported globally, characterized by gastrointestinal symptoms like diarrhea, and skin changes including alopecia, pigmentation, and nail atrophy. The syndrome is marked by the presence of diffuse polyps in the gastrointestinal tract, except the esophagus, with polyps being inflammatory, hyperplastic, hamartomatous, or adenomatous. CCS is associated with a high mortality rate due to its potential to lead to cancer and other complications. As of the date of the document, there was no standardized treatment for CCS, and the review aimed to enhance understanding of the disease.