Cronkhite–Canada Syndrome: From Clinical Features to Treatment

August 2020 in “ Gastroenterology report ”

Zeyu Wu, Li-Xuan Sang, Bing Chang

Studysummary This review discusses the characteristics and challenges in treating Cronkhite–Canada syndrome but reports no new clinical findings, emphasizing the need for better understanding and uniform treatment approaches. Our plain-language summary of this paper — not a Tressless recommendation.

Cronkhite–Canada syndrome (CCS) is a rare disorder with over 500 cases reported globally, characterized by gastrointestinal symptoms like diarrhea, and skin changes including alopecia, pigmentation, and nail atrophy. The syndrome is marked by the presence of diffuse polyps in the gastrointestinal tract, except the esophagus, with polyps being inflammatory, hyperplastic, hamartomatous, or adenomatous. CCS is associated with a high mortality rate due to its potential to lead to cancer and other complications. As of the date of the document, there was no standardized treatment for CCS, and the review aimed to enhance understanding of the disease.

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research Alopecia in Cronkhite-Canada Syndrome: Is It Truly Telogen Effluvium?

3 citations , May 2019 in “Australasian Journal of Dermatology”

This letter to the editors discusses the nature of alopecia in Cronkhite–Canada syndrome and questions whether it is truly telogen effluvium, but it reports no new clinical findings.

research A Case Report of Cronkhite-Canada Syndrome Complicated by Membranous Nephropathy

6 citations , November 2018 in “Case reports in nephrology and dialysis”

This case report detailed a 71-year-old male with Cronkhite-Canada syndrome and associated membranous nephropathy, who showed a significant improvement in skin and gastrointestinal symptoms, and remission of nephropathy, after treatment with rituximab, cyclosporine, and azathioprine.

research Nail Matrix Pathology in Cronkhite–Canada Syndrome: The First Case Report

8 citations , April 2017 in “American Journal of Dermatopathology”

In this study, nail matrix pathology in a patient with Cronkhite–Canada Syndrome revealed matrix hypergranulosis, suggesting that an inflammatory process may play a key role in the condition's pathogenesis.

research Alopecia Areata Incognita in Cronkhite-Canada Syndrome

7 citations , December 2016 in “British Journal of Dermatology”

This report presents evidence that alopecia areata incognita may be a possible mechanism of hair loss in patients with Cronkhite–Canada syndrome.

research Steroid Responsive Mononeuritis Multiplex in the Cronkhite-Canada Syndrome

1 citations , November 2016 in “Frontiers in neurology”

In this case report, a patient with Cronkhite-Canada syndrome also had mononeuritis multiplex, and the authors suggest that an autoimmune mechanism may be involved based on steroid responsiveness and electrophysiological findings.

research Cronkhite-Canada Syndrome (CCS)—A Rare Case Report

17 citations , January 2015 in “JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH”

This report presents a case of Cronkhite-Canada syndrome in an elderly Indian male, adding to the approximately 450 cases documented worldwide, but introduces no new results about the condition.

Cronkhite-Canada Syndrome: An Unusual Finding of Gastrointestinal Adenomatous Polyps in a Syndrome Characterized by Hamartomatous Polyps

research Cronkhite-Canada Syndrome: An Unusual Finding of Gastrointestinal Adenomatous Polyps in a Syndrome Characterized by Hamartomatous Polyps

5 citations , June 2014 in “Gastroenterology report”

This report describes a case of colonic adenomatous polyposis in a patient with Cronkhite-Canada syndrome, highlighting a deviation from the typically hamartomatous polyps and suggesting a need for further study.

Histopathological Insights Into Hair Loss in Cronkhite-Canada Syndrome: Diffuse Anagen-Telogen Conversion Precedes Clinical Hair Loss Progression

research Histopathological Insights Into Hair Loss in Cronkhite-Canada Syndrome: Diffuse Anagen-Telogen Conversion Precedes Clinical Hair Loss Progression

16 citations , May 2013 in “Australasian Journal of Dermatology”

In this study, detailed examinations of alopecic lesions in two female Cronkhite-Canada syndrome patients suggested hair regrowth might occur without systemic corticosteroids if not required for gastrointestinal treatment, and hair loss may begin with anagen-telogen transition.

research Cronkhite-Canada Syndrome Diagnosis in the Absence of Gastrointestinal Polyps

5 citations , March 2013 in “International journal of surgical pathology”

This case report illustrates that a diagnosis of Cronkhite-Canada syndrome can be made without the presence of polyps, as demonstrated by resolving symptoms with steroid treatment.

Cronkhite-Canada Syndrome Associated with Serrated Adenoma and Malignant Polyp: A Case Report and Literature Review of 13 Cases in Korea

research Cronkhite-Canada Syndrome Associated with Serrated Adenoma and Malignant Polyp: A Case Report and Literature Review of 13 Cases in Korea

21 citations , January 2013 in “Clinical Endoscopy”

This study reports the first case in South Korea of Cronkhite-Canada syndrome associated with malignant colon polyp and serrated adenoma.

research Case of Cronkhite-Canada Syndrome Shows Improvement with Enteral Supplements

6 citations , April 2012 in “PubMed”

This case report describes a 33-year-old Indian male with Cronkhite-Canada syndrome who experienced complete symptom recovery within 5 months after starting a high protein diet, proton pump inhibitors, and zinc-vitamin supplements.

research Twenty Nail Onychomadesis: An Unusual Finding in Cronkhite-Canada Syndrome

13 citations , June 2010 in “Journal of The American Academy of Dermatology”

This study reports previously unreported nail features in Cronkhite-Canada syndrome, specifically recurrent onychomadesis of all 20 nails linked to systemic illness.