Nail Matrix Pathology in Cronkhite–Canada Syndrome: The First Case Report

April 2017 in “ American Journal of Dermatopathology ”

Mati Chuamanochan, Napatra Tovanabutra, Pongsak Mahanupab, Sarawut Kongkarnka, Siri Chiewchanvit

Cronkhite–Canada Syndrome nail matrix pathology gastrointestinal polyposis nail dystrophy alopecia hyperpigmentation matrix hypergranulosis inflammatory process CCS nail abnormalities hair loss skin discoloration inflammation

TLDR Inflammation may cause nail issues in Cronkhite–Canada Syndrome.

The study reported the first case of nail matrix pathology in a patient with Cronkhite–Canada Syndrome (CCS), which is characterized by gastrointestinal polyposis and a triad of cutaneous abnormalities: nail dystrophy, alopecia, and hyperpigmentation. The histologic evaluation revealed matrix hypergranulosis, suggesting that an inflammatory process might play a significant role in the pathogenesis of CCS.

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Nail Matrix Pathology in Cronkhite–Canada Syndrome: The First Case Report

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