TLDR Steroids, infection management, and nutritional support can significantly improve symptoms of Cronkhite-Canada Syndrome.
Cronkhite-Canada Syndrome is a rare condition characterized by gastrointestinal polyposis, alopecia, and other symptoms. A case study of a 40-year-old female with this syndrome reported symptoms including abdominal pain, diarrhoea, alopecia, and hyperpigmentation. She experienced significant weight loss and nail changes. Histopathological examination showed polypoid mucosa and inflammatory changes in the colon. The patient also contracted Entamoeba histolytica and COVID-19, for which she received antibiotics and nutritional support. Her symptoms improved significantly after 4 weeks of corticosteroid treatment, highlighting the potential effectiveness of steroids, infection management, and nutritional counselling in alleviating symptoms.
5 citations
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September 2017 in “Medicine” A patient with Cronkhite-Canada Syndrome developed colon cancer that spread to the liver, showing the need for regular cancer checks in such patients.
21 citations
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January 2013 in “Clinical Endoscopy” First Korean case of Cronkhite-Canada syndrome with colon cancer and serrated adenoma.
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June 2015 in “Australasian Journal of Dermatology” A patient with Cronkhite-Canada syndrome improved with nutritional support and steroids, but early diagnosis is key due to high mortality.
16 citations
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May 2013 in “Australasian Journal of Dermatology” Hair loss in Cronkhite-Canada syndrome is reversible by treating the gut issues and doesn't need steroid treatment for the hair itself.
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November 2018 in “Case reports in nephrology and dialysis” Rituximab may be an effective treatment for Cronkhite-Canada syndrome with kidney disease.
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June 2014 in “Gastroenterology report” Cronkhite-Canada syndrome can sometimes show unusual colonic adenomatous polyps.
October 2024 in “Medicine” Cronkhite-Canada syndrome is rare, has a poor prognosis, and requires early diagnosis and ongoing treatment.
