Cronkhite-Canada Syndrome Associated with Colon Cancer Metastatic to Liver

In 2017, a case report described a 58-year-old male with Cronkhite-Canada Syndrome (CCS), who developed colon cancer with liver metastasis despite the previous belief that CCS polyps were benign. The patient presented with symptoms including diarrhea, weight loss, alopecia, and nail deformities, and was treated with dexamethasone acetate and FOLFOX6 chemotherapy. After over a year of treatment, colon cancer and adenomas were discovered, and subsequent surgeries confirmed hepatic metastasis of colonic adenocarcinoma. The patient remained stable for more than 2 years post-treatment. The study underscored the necessity of regular monitoring for malignancy in CCS patients and the urgent need for molecular markers to detect malignant transformation early. It also noted the importance of individualized treatment and highlighted the lack of large-scale trials for hormone therapy effectiveness in CCS.