A Forty-Two-Year-Old Male with Multiple Gastrointestinal Polyps, Cutaneous Manifestations, and Nail Dystrophy

March 2024 in “ Indian Journal of Dermatology ”

Tulika Rai, Neeraj Garg, Rajendra Kumar Mahawar, Soyza De

diffuse non-scarring alopecia alopecia skin dryness hyperpigmented macules Cronkhite-Canada syndrome hypothyroidism hair loss dark spots CCS

TLDR The man was diagnosed with Cronkhite-Canada syndrome, a rare disorder with GI polyps, skin issues, hair loss, and nail problems.

A 42-year-old male presented with chronic diarrhea, weight loss, and generalized weakness, accompanied by iron deficiency anemia, hypoproteinemia, and hypothyroidism. Physical examination revealed skin dryness, hyperpigmented macules, nail dystrophy, and diffuse non-scarring alopecia. Endoscopy showed multiple gastrointestinal polyps, and histopathology confirmed hyperplastic polyps. The diagnosis was Cronkhite-Canada syndrome (CCS), a rare non-hereditary disorder characterized by gastrointestinal polyposis, skin hyperpigmentation, alopecia, and nail dystrophy. Treatment focuses on nutritional support and symptom management, as no evidence-based treatment exists.

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