63 citations
,
September 2020 in “Frontiers in Microbiology” This review discusses the potential health benefits of probiotics as a "Bio-Therapy" in food and medicine, noting that more research is needed to fully understand their mechanisms and effectiveness.
61 citations
,
April 2021 in “Frontiers in Medicine” This study found that hidradenitis suppurativa significantly impaired quality of life in German patients, with severity linked to skin and certain extra-cutaneous changes, but not reduced by surgical or conventional medicamentous treatments.
61 citations
,
October 1996 in “Development” This study found that combining adult germinative epidermal cells with non-inductive dermal cells can stimulate hair follicle neogenesis, effectively altering the cells' status to enhance induction.
55 citations
,
August 2024 in “Heliyon” This review article highlights recent progress and challenges in stem cell transplantation for regenerative medicine, emphasizing its potential in tissue repair for conditions like bone and cartilage injuries, neurological disorders, and blood diseases, while stressing the importance of overcoming current obstacles for future advancements.
55 citations
,
April 2022 in “Frontiers in Immunology” This review examines the role of cholesterol metabolism in coronavirus infections, discussing its potential as a target for antiviral strategies and a marker for monitoring infection status, but presents no new results.
52 citations
,
January 2021 in “Journal of Thoracic Oncology” Effective vaccines and treatments are crucial for long-term COVID-19 control.
50 citations
,
April 2021 in “Frontiers in Immunology” This review discusses neuroimmune communication in skin disorders and peripheral neuropathic pain, highlighting the complex interactions between sensory neurons and immune cells; it reports no new clinical results but suggests potential future therapies.
49 citations
,
December 2022 in “Pharmacological Reviews” This review discusses androgen receptor targeting as a potential treatment strategy for triple-negative breast cancer and reports no new experimental outcomes.
46 citations
,
September 2022 in “International Journal of Environmental Research and Public Health” This study found that COVID-19 vaccine booster dose acceptance was high in the East Mediterranean Region, especially among those informed by the Ministry of Health, but concerns about benefits and side effects influenced rejection.
32 citations
,
August 2020 in “American Journal Of Pathology” This study reports that in ovarian high-grade serous carcinoma, overexpressed S100A4 likely promotes epithelial-mesenchymal transition and cancer stem cell properties, affecting tumor behavior through its interaction with NMIIA and mutant p53.
29 citations
,
March 2022 in “Biomedicines” This review discusses recent findings on cellular antioxidant responses to oxidative stress and their implications for treating various human diseases but reports no new clinical results.
26 citations
,
January 2024 in “Gels” This review highlights advancements in nanoemulgel platforms for topical and transdermal drug delivery, noting their improved safety and efficacy over conventional treatments in in vitro and in vivo studies, specifically for conditions like skin diseases and inflammatory issues.
26 citations
,
November 2022 in “European journal of medical research” This review discusses the potential of nanoparticles to modify angiogenesis processes for therapeutic applications and reports no new clinical results, highlighting challenges and future prospects in treating angiogenesis-related diseases.
26 citations
,
August 2008 in “Clinical endocrinology” This paper summarizes proceedings from a PCOS Special Interest Group, reporting recent advances in the understanding of PCOS follicular abnormalities, associated cardiovascular risks, and dermatological issues, but does not present new clinical findings.
24 citations
,
March 2020 in “Cells” This review provides an overview of natural product-derived small molecule modulators of the Wnt signaling pathway, exploring their potential as therapeutic agents for tissue regeneration and cancer treatment.
23 citations
,
July 2021 in “Life” This review evaluates the potential benefits and mechanisms of blue light therapy for skin conditions like atopic dermatitis and acne, but highlights the need for further research on safety and clinical protocols.
18 citations
,
May 2022 in “Stem Cell Research & Therapy” This study found that irradiating human adipose-derived stem cells with green OLEDs enhanced their wound healing capability and increased cell proliferation, migration, and adhesion in preclinical models.
16 citations
,
November 2021 in “Antioxidants” This review examines the role of oxidative stress in male hypogonadism associated with noncommunicable chronic diseases and discusses various management strategies, but it presents no new clinical findings.
16 citations
,
June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that DHHC13 is crucial for hair anchoring and skin barrier function, with its deficiency in Zdhhc13(skc4) mice leading to cyclic alopecia and skin abnormalities due to cornifelin deficiencies.
15 citations
,
January 2024 in “Journal of Materials Chemistry B” In this study, researchers developed an injectable silk fibroin-based hydrogel that enhances wound healing by protecting against oxidative stress and promoting tissue repair, outperforming commercial wound dressing Tegaderm™ in animal models.
14 citations
,
September 2025 in “Gels” This review reports that sodium alginate-based hydrogels show promise in biomedical applications due to their biocompatibility and versatility, but challenges such as mechanical strength and stability remain, highlighting the need for continued research to facilitate their clinical transition.
14 citations
,
November 2022 in “Archives of Dermatological Research” This study found that a green-light LED microneedle patch enhanced hair growth in mice with the best results among tested wavelengths, showing increased hair follicles and no serious side effects, suggesting its potential for treating androgenetic alopecia.
13 citations
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March 2020 in “Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy” This study used infrared spectroscopic imaging and scanning electron microscopy to reveal that alopecic hair has more irregular laminated structures and differing chemical profiles than normal hair, suggesting changes related to alopecia progression.
12 citations
,
June 2023 in “International Journal of Molecular Sciences” This review examines the potential of biomaterial-based wound dressings in managing diabetic foot ulcers, highlighting their versatility and therapeutic properties for promoting wound healing in individuals with diabetes mellitus.
12 citations
,
January 2021 in “Cell Transplantation” This study found that stem cells from human deciduous teeth promoted hair regeneration and increased hair formation in mice, suggesting a potential mechanism involving the Shh/Gli1 pathway.
10 citations
,
August 2023 in “Animals” In this study, researchers examined chicken feather follicle tissues from differently colored chickens and found that the genes SLC45A2 and GPNMB are involved in promoting melanin deposition, which enriches understanding of the genetic mechanisms affecting feather color.
10 citations
,
July 2022 in “Journal of Medicinal Chemistry” This article discusses the potential for combining PROTACs with other therapeutic modalities in drug discovery and reports no clinical results.
10 citations
,
April 2018 in “Journal of Mind and Medical Sciences” This article argues that the mind-body problem is a false issue, proposing that the mind merely temporally associates immaterial data with material support without actual interaction.
9 citations
,
July 2025 in “Pharmaceuticals” This review highlights the therapeutic potential of plant-derived exosomes, noting their larger size compared to animal-derived exosomes and usefulness in targeted drug delivery and inter-kingdom communication. It summarizes existing research on their biogenesis, characterization, and engineering for drug delivery, indicating significant opportunities for biotechnological advancements.
9 citations
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May 2025 in “Stem Cell Research & Therapy” This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.