Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States
April 2021
in “
Frontiers in Immunology
”
cutaneous neuroimmune interactions peripheral neuropathic pain inflammatory skin conditions sensory neurons immune responses allergic contact dermatitis atopic dermatitis psoriasis chronic neuropathic pain chemotherapy-induced peripheral neuropathy diabetic polyneuropathy high-concentration capsaicin patches neural-immune interactions capsaicin patches
TLDR New therapies targeting skin neuroimmune interactions could treat neuropathic pain.
The document discussed the intricate interactions between the skin's sensory nervous system and immune system, particularly in peripheral neuropathic pain and inflammatory skin conditions. It highlighted the role of sensory neurons in modulating immune responses, affecting conditions like allergic contact dermatitis, atopic dermatitis, and psoriasis. Dysregulated neuroimmune interactions were linked to chronic neuropathic pain, with specific focus on conditions such as chemotherapy-induced peripheral neuropathy and diabetic polyneuropathy. The study noted potential therapeutic approaches, including high-concentration capsaicin patches and targeting neural-immune interactions, as promising strategies for managing inflammatory skin diseases and neuropathic pain. The findings underscored the importance of understanding these interactions to develop effective treatments.
