January 1989 in “Oxford University Research Archive (ORA) (University of Oxford)” This study found that spironolactone effectively reduced hair growth in hirsute women over 12 months and was generally well tolerated.
This study found that spironolactone reduced hirsutism scores in women without significant hormonal changes, suggesting its effectiveness primarily through peripheral mechanisms.
October 1986 in “Inpharma” Spironolactone helps reduce hair growth in women with hirsutism but may cause menstrual irregularities.
This case study reports a pattern of psychogenic telogen effluvium with temporary hair loss following a C5 complete spinal cord injury, recovering fully except for minor hair loss at the occiput.
November 1982 in “Inpharma” Spironolactone reduces hair growth in women with unexplained excessive hairiness.
April 2021 in “Journal of Investigative Dermatology” This study found that oral spironolactone improved or maintained hair condition in females with scarring alopecia and female pattern hair loss, with 83% of patients tolerating the treatment well, despite some side effects like hyperkalemia and leg cramps.
April 2023 in “International Journal of Women's Dermatology” In this review, the authors reported that past concerns linking spironolactone to an increased risk of breast cancer are unfounded, citing recent studies that confirm no such association, indicating spironolactone's potential as a treatment for alopecia in women without fear of cancer recurrence.
April 2023 in “Journal of Investigative Dermatology” In this study, low-dose spironolactone reduced the severity of female pattern hair loss in a small group of women without causing significant side effects, suggesting it may be an effective and well-tolerated treatment option.
March 2023 in “Current Pharmaceutical Design” This study found that spironolactone significantly reduced hirsutism scores in women with idiopathic hirsutism compared to finasteride and cyproterone acetate but showed no significant difference among women with PCOS compared to flutamide and finasteride, and it was well tolerated overall.
March 2023 in “Clinical, Cosmetic and Investigational Dermatology” This study concluded that both oral and topical spironolactone effectively treat androgenetic alopecia, with topical administration being safer and suitable for any gender, especially when combined with minoxidil.
November 2022 in “Al-Azhar International Medical Journal (Print)” This study observed that combining 5% topical spironolactone with 5% topical minoxidil in a single dose could enhance treatment efficacy for androgenetic alopecia in both men and women, with significant hair growth improvements noted in group C after three months.
October 2022 in “British Journal of Dermatology” In this retrospective study, the incidence of hyperkalaemia within the first year of spironolactone use was assessed among women over 65 with female-pattern hair loss, highlighting a potential safety concern.
September 2022 in “Journal of The American Academy of Dermatology” This study measured hyperkalemia rates in women using spironolactone for acne, hair loss, and hirsutism to evaluate the necessity of laboratory monitoring, examining variations among different age, racial, and ethnic groups.
September 2022 in “Journal of The American Academy of Dermatology” In this study, the rate of hyperkalemia in women taking spironolactone for acne and related issues was low, but frequent monitoring of potassium trends during treatment may be advisable.
September 2022 in “Journal of The American Academy of Dermatology” This study examined the incidence of hyperkalemia in women over 65 with female pattern hair loss and spironolactone use, but the findings on risk remain unclear.
June 2020 in “The Medical Journal of Cairo University” In this study, topical spironolactone was found to be more effective than topical finasteride for treating androgenetic alopecia in both males and females, with fewer side effects compared to oral finasteride.
October 2019 in “International Journal of Research in Dermatology” This study found that combining topical minoxidil with oral spironolactone improved hair loss outcomes in women with female pattern hair loss when compared to minoxidil alone, but benefits plateaued after 6 months.
71 citations
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January 2011 in “Journal of cutaneous pathology” This case report describes the first confirmed instance of trichodysplasia spinulosa in a child with Down syndrome and leukemia, linking it to the TS-associated polyomavirus.
55 citations
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May 2007 in “Australasian journal of dermatology” This case report describes the characteristic clinicopathological features of trichodysplasia spinulosa in two boys with acute lymphocytic leukemia, highlighting its resolution as immune function normalizes.
40 citations
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November 2021 in “npj Regenerative Medicine” In this study, spiny mice showed superior cardiac recovery after myocardial infarction compared to other mouse strains, with enhanced myocardial preservation and functional stabilization.
33 citations
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January 2017 in “Journal of Cutaneous and Aesthetic Surgery” This study found that PRP injections improved hair density, quality, and thickness in males with androgenic alopecia compared to placebo, with reported high patient satisfaction and no major side effects.
33 citations
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November 2012 in “JAMA Dermatology” In this study, 14 out of 15 women with scalp dysesthesia also had cervical spine disease, and gabapentin improved symptoms for some patients.
30 citations
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February 2018 in “Journal of Pharmacy and Pharmacology” This review discusses the traditional uses and pharmacological properties of Hedychium spicatum, noting that while some traditional uses are supported by scientific studies, further research on its applications is needed.
28 citations
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November 2017 in “Molecular and cellular endocrinology” This review examines the roles of testosterone, dihydrotestosterone, and estradiol in activating male sexual behavior in laboratory animals and humans, reporting no new clinical results.
27 citations
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October 2002 in “International Journal of Dermatology” This study presents a microscopic analysis of the pruritic variant of trichostasis spinulosa in two patients and reviews existing literature, reporting no new clinical results.
26 citations
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December 1979 in “Journal of Cutaneous Pathology” This study found that trichostasis spinulosa was present in some seborrheic keratoses, indicating they may partly originate from hair follicle cells.
25 citations
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September 1973 in “Archives of dermatology” In this study, a daily topical application of a 0.05% tretinoin solution effectively removed dark plugs and resolved symptoms of trichostasis spinulosa.
19 citations
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March 2016 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, evidence that trichodysplasia spinulosa-associated polyomavirus targets follicular keratinocytes was observed in a pediatric case, suggesting these cells as the primary viral target.
19 citations
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December 2006 in “Archives of dermatology” This notice provides information about JAMA Dermatology's website usage policy, and no research findings are reported.
17 citations
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December 1994 in “International Journal of Dermatology” This article reports no new clinical findings but discusses two rare dermatological conditions, trichostasis spinulosa and eruptive vellus hair cysts, and their simultaneous occurrence.