Retrospective Study of the Prevalence of Hyperkalemia in Women Taking Spironolactone for Acne, Hair Loss, and Hirsutism
September 2022
in “
Journal of The American Academy of Dermatology
”
New to Spironolactone? There is a guide in the encyclopedia. Read the guide → Studysummary In this study, the rate of hyperkalemia in women taking spironolactone for acne and related issues was low, but frequent monitoring of potassium trends during treatment may be advisable.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This retrospective study examined the prevalence of hyperkalemia in 974 women taking spironolactone for acne, hair loss, and hirsutism. Out of 1273 courses of spironolactone, 447 courses (35.1%) showed an increase in potassium levels from baseline to end, with 171 courses (13.4%) showing an increase of ≥10%. Only 25 courses (2.0%) had end potassium values outside the upper limit of normal. Age, race, ethnicity, course duration, and cumulative dose were not significant predictors of hyperkalemia. The study concluded that while the overall rate of hyperkalemia was low, dermatologists should monitor potassium trends during treatment, especially in patients with a history of elevated potassium levels.
