Hair Casts and Cutaneous Spicules in Multiple Myeloma

December 2006 in “ Archives of dermatology ”

Jeffrey J. Miller, Bryan Anderson, Michael D. Ioffreda, Michael B. Bongiovanni, Anneli C. Fogelberg

hair casts cutaneous spicules hyperkeratosis parakeratosis monoclonal IgG protein eosinophilic material chemotherapy

TLDR Hair casts and cutaneous spicules can be signs of multiple myeloma.

The document described a case of a 70-year-old woman with multiple myeloma who exhibited cutaneous spicules on her nose and hair casts on her scalp and eyelashes. Biochemical analysis confirmed that these spicules and hair casts contained monoclonal IgG protein, the same as found in her serum. Histopathologic examination revealed hyperkeratosis and parakeratosis in the spicules and amorphous eosinophilic material in the hair casts. Despite various topical treatments, significant improvement was only observed after chemotherapy, which reduced her serum IgG levels. The study proposed that hair casts should be recognized as a characteristic finding in multiple myeloma, alongside cutaneous spicules.

View this study on jamanetwork.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Neck tension, and hair loss, I am 100 percent sure that there is a connection

in Treatment 19 upvotes 6 months ago

The user believes neck tension and poor posture contribute to hair loss, noticing improvements with yoga and muscle relaxation. Replies suggest androgenic alopecia as the cause and recommend exercises.

community Why is everyone not directly advised Dutasteride?

in Finasteride/Dutasteride 165 upvotes 1 month ago

Dutasteride is less commonly prescribed for hair loss because it is not FDA-approved for this purpose, unlike finasteride, which is more accessible and preferred due to fewer side effects. Dutasteride may be more effective in reducing DHT but has a longer half-life and potentially more significant side effects.

community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

in Research/Science 108 upvotes 1 year ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

community Homemade topical spironolactone

in Research/Science 26 upvotes 2 years ago

The potential effectiveness of homemade topical spironolactone in treating hair loss, with studies suggesting it is more effective than finasteride and even minoxidil when used as monotherapy. The conversation also mentions that other anti-androgens are being developed which may soon hit the market.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Retin-a (tretinoin) increase effect of minox

in Minoxidil 27 upvotes 5 years ago

The conversation discusses how applying topical tretinoin for 5 days can convert 43% of individuals who initially do not respond to minoxidil into responders, enhancing the effect of minoxidil on hair growth. Specific treatments mentioned are minoxidil and tretinoin.

Similar Research

5 / 1000+ results

research General Dermatology: Comprehensive Overview of Dermatological Conditions

January 2017 in “Springer eBooks”

The document explains various skin conditions and their treatments.

research Multiple Minute Digitate Hyperkeratosis

9 citations, July 2002 in “Journal of the European Academy of Dermatology and Venereology”

The document concludes that fexofenadine reduces inflammation in chronic hives, cholestyramine helps half of pregnant women with itchy rashes, and relaxing incisions are a good alternative in facial surgery for the elderly.

Alternative Uses of Dermoscopy in Daily Clinical Practice: An Update