Spironolactone in the Treatment of Hirsutism

    January 1987 in “ PubMed ”
    Leena Anttila, Kristiina Ruutiainen, Risto Erkkola
    TLDR Spironolactone was effective in reducing hair growth in women with hirsutism.
    In a study conducted 37 years ago, 18 women with hirsutism were treated with 100 mg of Spironolactone daily. The severity of hirsutism was evaluated using the Ferriman and Gallwey scale, and various hormone levels were measured before and after six months of treatment. The study found that 12 of the women showed a clinical response, with the total hirsutism score for the entire group decreasing from 14.1 +/- 6.3 to 11.8 +/- 6.4 (p less than 0.01). No changes were observed in the hormonal values. The results confirmed the effectiveness of Spironolactone in reducing hair growth, primarily through a peripheral mode of action.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 322 results

      community AA and Hirsutism but T levels are normal

      in Female  6 upvotes 3 years ago
      27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

      community Spironolactone or bicalutamide prescription

      in Treatment  4 upvotes 1 year ago
      The conversation is about someone seeking a doctor in the EU who prescribes spironolactone or bicalutamide for female pattern hair loss, as they are having difficulty finding treatment options beyond Minoxidil in Austria. They are asking for recommendations and are open to direct messages for assistance.

      community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

      in Progress Pictures  224 upvotes 6 months ago
      A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  57 upvotes 10 months ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community No, Finasteride as a treatment for MPB was not an "accident"

      in Research/Science  105 upvotes 3 years ago
      Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

      community Any balding females? I need advice with coping :(

       16 upvotes 8 years ago
      A 27-year-old woman is struggling with hair loss, feeling self-conscious and seeking advice on coping. She mentions trying Minoxidil but is hesitant due to scalp issues and is looking for ways to regain confidence.

    Similar Research

    5 / 1000+ results