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This review discusses autologous tissue engineering strategies and skin-derived stem cell transplantation products, noting clinical challenges and highlighting ongoing trial activities, without reporting new clinical outcomes.

This review discusses the generation of germ cell-like cells from skin-derived stem cells and reports no new results; the potential for these cells to produce viable progeny remains unclear.

This study reports that a single intradermal injection of autologous adipose-derived stem cells improved visible aging signs such as wrinkles and pore size on facial skin for over a year in eight patients, with in vitro data suggesting muscle involvement in the rejuvenation process.

This study found that adipose-derived stem cell extracellular vesicles reduced wrinkles and promoted cell proliferation in UVB-induced photoaging in mice by decreasing oxidative stress and inflammation.

This study developed a new protocol to efficiently produce skin dermal stem cells from human induced pluripotent stem cells, which may aid in treating various skin disorders.

This review discusses the potential of adipose-derived stem cells for treating vitiligo, hair loss, and chronic wound healing, but reports no new clinical results and suggests the need for further investigation.

This study demonstrated that cultured epidermal stem cells and skin-derived precursors can regenerate functional hair follicles and sebaceous glands in both mice and adult humans, suggesting potential for bioengineered skin substitutes.

This study found that adipose-derived stem cell-conditioned media improved skin flap survival following ischemia/reperfusion injury in mice by increasing cell proliferation and the number of hair follicles, mediated by IL-6.

This study found that UVB irradiation alters skin stem cell niches leading to signs of photoaging, which may be reversed by adipose-derived stem cells through BMP4 pathway modulation and niche remodeling.

In this study, co-administering adipose-derived stem cells with platelet-rich plasma reduced radiation therapy-induced skin and hair follicle damage in mice, suggesting potential for clinical application.

This review presents evidence supporting the potential of adipose-derived stem cell secretome as a promising cell-free therapy for skin repair, emphasizing its application in wound healing, alopecia, skin rejuvenation, and inflammatory skin diseases.

This review highlights the potential of exosomes as a novel therapeutic approach for skin diseases and aging, due to their stability, transportability, and ability to carry various bioactive compounds to target cells.

The authors concluded that burned skin contains viable mesenchymal stem cells which enhance wound healing in animal models without altering key biological functions due to burn trauma.

This review examines the potential mechanisms by which stem cell-derived cell-free therapy may prevent skin aging, highlighting various molecular targets and pathways involved in regeneration, oxidative stress regulation, ECM preservation, cell activity modulation, and inflammation.

In this study, researchers found that while both hair follicles and skin dermis-derived neural crest stem cells are suitable for large-scale manufacturing, skin dermis cells grow faster and are easier to obtain.

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

This review explores the role of hair follicle dermal stem cells in skin regeneration and restorative therapies, but it reports no new experimental results.

Exosomes and stem-cell therapies slightly outperform PRP in improving hair and skin, but more research is needed.

Exosomes and stem-cell therapies slightly outperform PRP in improving hair and skin, but more research is needed.

This study developed an efficient method for isolating and enriching multipotent ovine hair follicle stem cells, which may aid in research on the ovine hair cycle and future wool production.

In this pilot study, researchers isolated skin-derived precursor-like cells from human-induced pluripotent stem cell-derived skin organoids, revealing their potential for future hair regenerative applications by exhibiting self-renewal and key marker expression.

This review provides an overview of current research on AD-MSCs, PRP, and biomaterials, highlighting their safety and efficacy in treating soft tissue defects and chronic wounds without major side effects.

This study provided an overview of skin organoids created from pluripotent stem cells, showcasing their potential in dermatologic research and future clinical applications, while noting challenges such as lengthy differentiation protocols that result in heterogeneous products.

This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.

This study reported that mSKPs and DMSCs share similarities in biological characteristics but exhibit distinct transcriptome profiles, with mSKPs being more immune-related and DMSCs more associated with differentiation and disease pathways.

In a rat skin wound model, this study observed that a composite dressing using chitosan hydrogel and exosomes derived from adipose mesenchymal stem cells enhanced wound healing by promoting collagen deposition, angiogenesis, and regeneration of hair follicle structures.

In this study, researchers demonstrated that fibroblasts derived from human embryonic stem cells can be used to create tissue-engineered dermal substitutes, effectively repairing mouse skin wounds within 20 days, highlighting a promising method for clinical applications in skin repair.

This study concluded that hair-derived stem cells from older donors may offer a promising alternative for autologous corneal endothelial replacement, potentially benefitting patients of various age groups.

In this study, the researchers developed a new protocol using human-induced pluripotent stem cells to efficiently create skin hair follicle organoids, which may aid in optimizing hair follicle growth and exploring treatments for alopecia.

This study reported that bio-pulsed avian-derived mesenchymal stem cell extracellular vesicles significantly improved cell proliferation, wound healing, and gene expression in human skin fibroblasts and hair follicle cells.