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Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

Using skin stem cells and certain molecules might lead to scar-free skin healing.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

The article concludes that studying how skin forms is key to understanding skin diseases and improving regenerative medicine.

Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.

The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.

The HR protein's role as a repressor is essential for controlling hair growth.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Blocking JAK-STAT signaling can lead to hair growth.

Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

The Hairless gene is crucial for healthy skin and hair growth.

Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.

FGF21 can help reduce skin inflammation caused by C. acnes.

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

Loss of a specific protein in skin cells causes symptoms similar to psoriasis.

Researchers discovered potential origins and new treatments for skin cancer, including biomarkers for melanoma and therapies that reduce tumor growth.

Edar signaling is crucial for proper hair follicle development and function.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

Epimedium extract helps increase skin pigmentation and could be a new treatment for conditions with reduced pigmentation.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.

Wnt, Eda, and Shh pathways are crucial for different stages of sweat gland development in mice.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

Certain genes are more active in baby scalp cells and can help grow hair when added to adult mouse skin cells.

Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.

Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.

Skin cells called dermal fibroblasts are important for skin growth, hair growth, and wound healing.