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    Glossary Skin Organoids

    miniature lab-grown skin tissues mimicking real skin functions

    Skin organoids are miniature, simplified versions of skin tissue that are grown in a lab from stem cells. They mimic the structure and function of real skin, including the development of hair follicles and sebaceous glands, making them valuable for studying skin diseases, testing drugs, and potentially for regenerative medicine.

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    1. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018 · 169 citations
    2. Skin organoids: A new human model for developmental and translational research Experimental Dermatology · 2021 · 31 citations
    3. Self‐organizing hair peg‐like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field Experimental Dermatology · 2019 · 26 citations
    4. Generation of Skin Organoids: Potential Opportunities and Challenges Frontiers in cell and developmental biology · 2021 · 20 citations
    5. Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids Stem cell reports · 2022 · 14 citations
    6. The empowering influence of air-liquid interface culture on skin organoid hair follicle development Burns & Trauma · 2024 · 9 citations
    7. Generation of human-induced pluripotent stem cell-derived adherent 3-dimensional skin hair-follicle organoids Organoid · 2022 · 2 citations
    8. Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System Journal of Visualized Experiments · 2025 · 1 citations
    9. Applications of Human Pluripotent Stem Cell–Derived Skin Organoids in Dermatology 2023 · 1 citations
    10. Construction strategies of skin organoids: A review Organoid Research · 2026
    11. Progress and perspectives on hydrogel-assisted skin organoids Organoid Research · 2026
    12. RNA Coding and Transcriptional Regulation in Skin Repair: Insights from Single-Cell Profiling and Implications for Organoid-Based Regenerative Strategies Life · 2026
    13. Dermal Microvascular Responses of Human Induced Pluripotent Stem Cell–Derived Skin Organoids to Inflammation and Injury American Journal Of Pathology · 2026
    14. Skin Organoids for Disease Modelling, Drug Screening and Regenerative Medicine: Recent Advances and Future Perspectives Wound Repair and Regeneration · 2026
    15. Human pluripotent stem cell-derived skin organoids enabled pathophysiological model of Mycobacterium tuberculosis infection Nature Communications · 2025
    16. 0887 Long-lived and genetically-diverse skin organoids derived from murine adult hair follicle stem cells Journal of Investigative Dermatology · 2025
    17. Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C Advanced Science · 2025
    18. Organoids in skin wound healing Burns & Trauma · 2024
    19. Generating Skin‐Derived Precursor‐Like Cells From Human‐Induced Pluripotent Stem Cell‐Derived Skin Organoids Experimental Dermatology · 2024
    20. 779 Multicellular skin organoids as a unique modeling platform for skin physiology, injury, and disease Journal of Investigative Dermatology · 2024
    21. Modeling of solar UV-induced photodamage on the hair follicles in human skin organoids Journal of tissue engineering · 2024
    22. LB1774 Establishing competent morphogenetic fields for tissue pattern regeneration in skin organoids Journal of Investigative Dermatology · 2023
    23. Bioengineered skin organoids: from development to applications Military Medical Research · 2023
    24. 1439 Development of a complex skin organ in human induced pluripotent stem cell-derived organoids 2023
    25. Mechanical force drives the initial mesenchymal-epithelial interaction during skin organoid development Theranostics · 2023
    26. 707 Guiding skin organoid generation via extracellular matrix cues and spatially controlled morphogen gradients 2022
    27. 3D bioprinting of hepatocyte-derived exosome-reinforced skin organoid for efficient skin regeneration Nano Research · 2026
    28. A skin organoid-based infection platform identifies an inhibitor specific for HFMD Nature Communications · 2025
    29. Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures Frontiers in cell and developmental biology · 2021 · 5 citations
    30. Integrating stem cell biology and organoid technology for skin regenerative therapies Health engineering. · 2025