Guiding Skin Organoid Generation via Extracellular Matrix Cues and Spatially Controlled Morphogen Gradients

This study found that generating pluripotent stem cell-derived skin organoids in a 3D bioprinted hydrogel device improved keratinocyte differentiation and hair follicle formation while reducing necrosis.

Skin organoids can regenerate hair by forming specific cell units with certain signals.

In this study, iPSC-derived epidermal organoids demonstrated potential as a novel tool for regenerative medicine by producing high-performance extracellular vesicles that promote proliferation, migration, and angiogenesis in cell-free therapies for wound healing.

This study demonstrated that hiPSC-derived hair-bearing skin organoids lacked sufficient type VII collagen at the epidermal-dermal junction, indicating a need for further maturation to model certain forms of epidermolysis bullosa effectively.

In this study, researchers presented a protocol for generating planar skin organoids from human induced pluripotent stem cells, which include hair follicles and other skin structures, offering a relevant in vitro model for investigating skin physiology, pathogen interactions, and drug responses.