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Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Targeted cancer therapies often cause serious skin problems that need careful management.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

Trichoscopy is a useful tool for diagnosing different hair and scalp diseases by their unique visual features.

Hair stem cell regeneration is controlled by signals that can explain different hair growth patterns and baldness.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Some medicinal plants can help heal wounds and may lead to new treatments.

Pectin biosynthesis is essential for the growth of cotton fibers and Arabidopsis root hairs.

High androgen levels in young women with PCOS are linked to higher blood pressure.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Mostly postmenopausal Caucasian women get Frontal Fibrosing Alopecia, which often includes eyebrow loss and has limited treatment success.

Myrtle has various health benefits and potential for medicine development.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

Blocking JAK-STAT signaling can lead to hair growth.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

DrugNet effectively identifies new uses for existing drugs and may save resources in drug development.

Some people with pattern hair loss may also have scalp inflammation and scarring similar to lichen planopilaris.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Lichen planus is a skin condition that can resolve on its own, is linked to hepatitis C, and increases the risk of skin cancer.

Male pattern baldness involves genetics, hormones, and needs better treatments.