HLA-B Alleles Associated With Frontal Fibrosing Alopecia In Brazil May Share Similar Peptide Presentation And T-Cell Interaction Profiles

February 2024 in “ Journal of the European Academy of Dermatology and Venereology ”

Hélio Amante Miot, Lorena Dourado Alves, Erick C. Castelli, Camila Ferreira Bannwart Castro, Joyce Machado Silva, Celso Teixeira Mendes‐Junior, Gustavo Fioravanti Vieira, Renata Fioravanti Tarabini, Etiele de Senna Silveira, Paulo Müller Ramos

HLA-B alleles frontal fibrosing alopecia FFA peptide presentation T-cell interaction genetic factors immune response mechanisms HLA-B

This study investigates the association between HLA-B alleles and frontal fibrosing alopecia (FFA) in a Brazilian population. The research suggests that certain HLA-B alleles may share similar peptide presentation and T-cell interaction profiles, potentially contributing to the pathogenesis of FFA. The findings highlight the importance of genetic factors in the development of this condition and suggest that these alleles could be involved in the immune response mechanisms underlying FFA. The study emphasizes the need for further research to explore these genetic associations and their implications for understanding and treating FFA.

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research Frontal Fibrosing Alopecia: Demographic and Clinical Characteristics of 490 Cases

53 citations , June 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Frontal fibrosing alopecia mainly affects postmenopausal women and may be linked to thyroid hormones.

research Genome-Wide Association Study in Frontal Fibrosing Alopecia Identifies Four Susceptibility Loci Including HLA-B*07:02

115 citations , March 2019 in “Nature Communications”

Frontal fibrosing alopecia is linked to four genetic areas, especially the HLA-B*07:02 allele.

Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A*33:01; B*14:02; C*08:02 as a Genetic Marker

research Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A33:01; B14:02; C*08:02 as a Genetic Marker

7 citations , January 2019 in “Australasian Journal of Dermatology”

A genetic marker linked to a type of hair loss was found in most patients studied.