research HLA‐B alleles associated with frontal fibrosing alopecia in Brazil may share similar peptide presentation and T‐cell interaction profiles
Certain genetic factors may contribute to frontal fibrosing alopecia in Brazil.
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5 / 1000+ resultsresearch T-cell “induced-self” MHC class I/peptide complexes may enable “de novo” tolerance induction to neo-antigens occurring outside of the thymus
This paper proposes that the induction of HF-specific neo-antigens by peripheral CD8+ T cells may maintain self-tolerance but could also lead to immunopathology in conditions like alopecia areata.
research The Immune Functions of Keratinocytes in Skin Wound Healing
This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.
research Evaluation of A Pool of Biomimetic Peptides on Human Hair Follicles: A Preclinical Study
This preclinical study reported that the mix of biomimetic peptides, MGF, promoted hair growth and increased cell proliferation in cultured human hair follicles from AGA subjects.
research Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege
This study suggests that the neuropeptide CGRP may protect against, but not restore, IFNγ-induced collapse of hair follicle immune privilege in alopecia areata.
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5 / 515 resultscommunity dut/min /copper peptides VS PP405 results
Minoxidil, dutasteride, and copper peptides are used in a tattooing method for hair regrowth, with some users noting better results compared to oral treatments. Copper peptides are considered to have minimal impact, but the method may reduce side effects.
community Will we be able to watch the Pelage PP405 presentation live online somewhere?
The conversation is about interest in watching the Pelage PP405 presentation online, with mentions of hair loss treatments like finasteride. Users express frustration and humor about the topic, with one user noting finasteride caused discomfort.
community 2 years on finasteride - holding steady, but not much regrowth
The user has been on finasteride for two years, experiencing maintenance of hair without significant regrowth, and is considering adding minoxidil for potential improvement. They are generally satisfied with the results and are exploring other options like peptides and possibly a hair transplant in the future.
community Coegin Pharma to release Follicopeptide (FOL005) by Q2 2025
Follicopeptide (FOL005) by Coegin Pharma will launch as a cosmetic hair growth treatment by Q2 2025, showing similar efficacy to finasteride. Users discuss the benefits and skepticism of releasing hair loss treatments as cosmetics rather than drugs.
community Pelage PP405: New Hair Growth from Inactive Follicular Units - Phase 2a results at AAD 2026
PP405, a topical treatment, shows promise for hair growth by activating inactive follicles, with 66% of participants experiencing positive results. The treatment is well-tolerated and may proceed directly to Phase 3 trials, offering a potential alternative to minoxidil and finasteride.
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8 / 800 results- Is PP405 a peptide that protects follicles from DHT? PP405 is not a peptide and does not block DHT: it is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, aimed at waking dormant follicles. Its registered Phase 2 trial (NCT06393452) measured safety and tolerability in 78 adults with pattern hair loss; it is not approved and not for sale.
- Can retinol help enhance the absorption of ingredients like minoxidil or peptides? No human study has measured whether retinol increases scalp absorption of minoxidil or peptides. Retinoids thicken rather than thin the epidermis, and they can irritate skin and need caution in pregnancy.
- Do alopecia areata patches scar? And is there evidence for peptides? Alopecia areata patches usually still have living follicles and often regrow. One small trial of a cosmetic peptide lotion reported improvement, but no peptide is an approved treatment; see a dermatologist.
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