Evaluation of a Pool of Biomimetic Peptides on Human Hair Follicles: A Preclinical Study

In a preclinical study conducted in 2019, a mix of biomimetic peptides (MGF) was found to stimulate hair growth in human hair follicles from subjects with Androgenetic Alopecia (AGA). The study involved 400 hair follicles from 10 AGA subjects and tested the effects of MGF in different culture conditions. The results showed that MGF induced a higher hair shaft elongation compared to media alone, with a statistically significant stimulation of hair shaft measured at 96 hours of treatment (p<0.05, WM + MGFs vs WM and p<0.01, NM + MGFs vs NM). The presence of MGF also promoted the hair growth anagen phase, as indicated by a decrease in hair cycle score (p<0.05, WM + MGF vs WM and NM + MGF vs NM). Furthermore, the levels of Ki-67, a marker of cellular proliferation, showed a significant preservation of proliferative activity with MGF treatment. Therefore, MGF was concluded to be a useful therapeutic agent for stimulating hair growth by promoting the anagen phase and cell proliferation.