TLDR Biomimetic peptides were found to promote hair growth and prolong the growth phase in human hair follicles.
In a preclinical study conducted in 2019, a mix of biomimetic peptides (MGF) was found to stimulate hair growth in human hair follicles from subjects with Androgenetic Alopecia (AGA). The study involved 400 hair follicles from 10 AGA subjects and tested the effects of MGF in different culture conditions. The results showed that MGF induced a higher hair shaft elongation compared to media alone, with a statistically significant stimulation of hair shaft measured at 96 hours of treatment (p<0.05, WM + MGFs vs WM and p<0.01, NM + MGFs vs NM). The presence of MGF also promoted the hair growth anagen phase, as indicated by a decrease in hair cycle score (p<0.05, WM + MGF vs WM and NM + MGF vs NM). Furthermore, the levels of Ki-67, a marker of cellular proliferation, showed a significant preservation of proliferative activity with MGF treatment. Therefore, MGF was concluded to be a useful therapeutic agent for stimulating hair growth by promoting the anagen phase and cell proliferation.
8 citations,
January 2016 in “Annals of Dermatology” A complex of 5-aminolevulinic acid and glycyl-histidyl-lysine peptide may help increase hair count in male pattern hair loss without side effects.
7 citations,
December 2015 in “Experimental Dermatology” Sh-Polypeptide 9 may be better than minoxidil for hair growth and protection against damage.
165 citations,
January 2008 in “Journal of biomaterials science. Polymer ed.” The peptide GHK-Cu helps heal and remodel tissue, improves skin and hair health, and has potential for treating age-related inflammatory diseases.
53 citations,
September 2007 in “Annals of the New York Academy of Sciences” Thymosin beta 4 helps hair grow by boosting stem cell activity.
98 citations,
December 2003 in “The FASEB Journal” Thymosin β4 promotes hair growth by activating stem cells in hair follicles.
19 citations,
May 2020 in “Cells” Substance from human umbilical cord blood cells promotes hair growth.
Peptide hydrogels show promise for healing skin, bone, and nerves but need improvement in stability and compatibility.
8 citations,
December 2018 in “Journal of Dermatological Treatment” The PRP-like cosmetic with biomimetic peptides is potentially effective and safe for treating alopecia areata.
The combined treatment increased hair density in most patients with Androgenetic Alopecia.
January 2018 in “journal of applied pharmaceutical science” Biomimetic peptides improved hair growth and increased growth factors in hair follicles for hair loss patients.
