Contact Dermatitis Associated With Nail Care Products: Retrospective Analysis of North American Contact Dermatitis Group Data, 2001–2016

April 2020 in “ Dermatitis ”

Erin M. Warshaw, Lindsey M. Voller, Jonathan I. Silverberg, Joel G. DeKoven, Amber Reck Atwater, Howard I. Maibach, Margo J. Reeder, Denis Sasseville, D. Belsito, Vincent A. DeLeo, Anthony F. Fransway, Joseph F. Fowler, James S. Taylor, Melanie D. Pratt, Toby C.G. Mathias, James G. Marks, Kathryn A. Zug, Matthew Zirwas

contact dermatitis hair care products p-phenylenediamine methylisothiazolinone methylchloroisothiazolinone cocamidopropyl betaine shampoo conditioners patch test allergens scalp hair dye MIT CMIT CAPB

Studysummary This study found that 9% of tested patients had positive patch test reactions linked to hair care products, with most reactions clinically relevant and commonly involving allergens like p-phenylenediamine.

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This retrospective analysis of North American Contact Dermatitis Group data from 2001 to 2016 examined the prevalence of contact dermatitis associated with hair care products (HCPs) among 38,775 patients. It found that 9.0% of patients had positive patch test reactions linked to HCPs, with a higher prevalence in females and dermatitis primarily affecting the face and scalp. The study identified p-phenylenediamine, methylisothiazolinone, methylchloroisothiazolinone/methylisothiazolinone, and cocamidopropyl betaine as common allergens. Hairdressers and cosmetologists were the most affected occupational group. Shampoo and conditioners were the most frequent sources of reactions. The study highlighted that 18.5% of HCP-positive patients reacted to allergens not included in the standard screening, emphasizing the need for expanded patch testing.

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