Skin Diseases Associated With Atopic Dermatitis

The document from September 1, 2018, reviews the association between atopic dermatitis (AD) and various skin diseases, including autoimmune conditions like alopecia areata (AA) and vitiligo. It reports that AD patients with filaggrin (FLG) gene mutations have an increased risk of developing other skin conditions, with odds ratios (OR) of 151.85 for those with two FLG null mutations and 7.44 for heterozygous mutations. A cohort study with over 3 million subjects found AD patients were 55% more likely to develop impetigo, and a Danish study with 8,112 AD patients found a strong association between AD and AA (OR 26.31). A meta-analysis showed 2-3 times higher odds of AD in AA patients, and another meta-analysis found higher odds of AD in vitiligo patients (OR 7.82). The document suggests that shared genetics and immune pathways may contribute to the association between AD and these skin diseases, and larger studies are needed to confirm these correlations.