TLDR Depression and skin autoimmune diseases are linked, needing combined care for better treatment.
The review examines the significant correlation between depressive disorders and dermatological autoimmune diseases, suggesting a shared pathomechanism through inflammatory pathways. A cohort study from Taiwan with over 200,000 patients found a significant risk of autoimmune comorbidities in those with major depressive disorder. Psoriasis, atopic dermatitis, and alopecia areata show a bidirectional relationship with depression, partly due to elevated pro-inflammatory cytokines like TNF-α and interleukins. The review emphasizes the need for integrated care approaches to address both mental and dermatological health, highlighting the importance of understanding these shared mechanisms to improve treatment and management of these comorbid conditions.
4 citations
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November 2022 in “Frontiers in Medicine” People with alopecia areata are more likely to have anxiety and depression and a lower quality of life.
15 citations
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July 2021 in “JAMA Dermatology” Androgenetic alopecia negatively affects quality of life and self-esteem, especially in women, but not depression.
57 citations
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April 2019 in “British journal of dermatology/British journal of dermatology, Supplement” Alopecia areata involves immune system imbalances that may lead to depression and anxiety.
37 citations
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January 2019 in “JAMA Dermatology” People with Major Depressive Disorder have a higher chance of getting Alopecia Areata, and vice versa; antidepressants may lower this risk.
191 citations
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May 2018 in “British journal of dermatology/British journal of dermatology, Supplement” Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.
26 citations
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January 2017 in “Acta dermato-venereologica” Antidepressants might help with skin inflammation and improve conditions like psoriasis and eczema.
October 2023 in “Acta dermato-venereologica (Print)” People with severe hair loss have lower zinc levels in their blood.
