Effect of Microneedling Associated With Drug Delivery on Facial Rejuvenation: Clinical and Histological Evaluation

    April 2021 in “ International Journal Of Medical Science And Clinical Invention ”
    Rafaella Rêgo Maia, Rodrigo Otávio Silveira Silva, Stephany Luanna Queiroga Farias, Liliane Santos de Vasconcellos, Eneida de Morais Carreiro, Patrí­cia Froes Meyer, Fábio dos Santos Borges, Felipe Alexander Caldas Afonso, Fernando César Oliveira, Ciro Dantas Soares, Joyce Rodrigues
    TLDR Microneedling with growth factors improves facial rejuvenation more than microneedling with saline.
    The study investigated the effects of microneedling combined with drug delivery on facial rejuvenation in 30 volunteers with facial aging, divided into two groups. Group 1 received microneedling with saline, while Group 2 received microneedling with growth factors. Both groups underwent two treatment sessions. Results showed that both groups had satisfactory clinical outcomes, but Group 2 demonstrated significant improvements in facial symmetry and a greater increase in collagen and elastin, particularly type I collagen, compared to Group 1. The study concluded that microneedling with growth factors enhanced collagen production and connective tissue reorganization more effectively than microneedling without additional cosmetological agents.
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