Follicular Mycosis Fungoides Associated With Lithium

February 2001 in “ Journal of the American Academy of Dermatology ”

George J. Francis, Alan R. Silverman, Osama M. Saleh, Grace J. Lee

follicular mycosis fungoides alopecia follicular hyperkeratosis comedo-like lesions epidermal cysts lymphoma cells hair follicles lithium carbonate haloperidol pseudolymphoma hair loss skin cysts skin lesions

TLDR Lithium can cause skin changes similar to mycosis fungoides.

Follicular mycosis fungoides is a rare disease characterized by alopecia, follicular hyperkeratosis, comedo-like lesions, and acquired epidermal cysts, with lymphoma cells invading hair follicles. This report highlighted the first case of pseudolymphoma of the follicular mycosis fungoides type in a patient taking lithium carbonate, suggesting that lithium or a combination of lithium and haloperidol can induce mycosis fungoides-like skin changes. Dermatologists should be aware of this potential side effect in patients undergoing such treatments.

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