Folliculotropic Mycosis Fungoides: Prognosis and Treatment

Folliculotropic mycosis fungoides (FMF) is a variant of mycosis fungoides with a worse prognosis, now divided into indolent and aggressive subtypes. Indolent FMF has a 5-year survival rate of 92% and a 10-year rate of 72%, while aggressive FMF has significantly lower rates of 55% and 28%, respectively. FMF with internal organ involvement drastically reduces survival rates to 23% at 5 years and 2% at 10 years. Diagnosis is complicated by various clinical and histopathological subtypes. Treatment includes topical and systemic therapies, with allogeneic hematopoietic stem cell transplantation (allo-HSCT) considered for non-responsive cases. Chemotherapy is typically a temporary solution and used as a bridge to allo-HSCT.