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This review discusses the potential risks of ejaculatory dysfunction associated with both medical and surgical treatments for lower urinary tract symptoms due to benign prostatic hyperplasia and their implications for male fertility, but it reports no new clinical results.

This case study of a subfertile couple highlighted the importance of considering haemochromatosis, particularly involving the C282Y mutation of the HFE gene, in patients with endocrine disorders linked to hypogonadism.

In this animal study, administering testosterone alongside a 5α-reductase inhibitor counteracted testosterone's effects on prostate enlargement while preserving its beneficial effects on muscle and bone.

Using testosterone-stimulated weanling rats can effectively replace castrated rats for anti-androgen testing, reducing animal stress.

In this case report, a 48-year-old woman's hyperandrogenism, presenting with symptoms like acne and hirsutism, was attributed to a benign Leydig cell tumor, which resolved after surgical removal.

This study found that finasteride effectively reduced cardiac hypertrophy and improved heart function in male mice, suggesting a potential role of DHT in cardiac remodeling and highlighting 5-α-reductase inhibition as a possible therapy.

This study found that melatonin implants caused male weasels to molt, develop a new white winter coat, and become reproductively inactive, suggesting melatonin affects their neuroendocrine system.

This study found that 1-year use of 5alpha-reductase inhibitors, dutasteride or finasteride, significantly lowered dihydrotestosterone levels without adversely affecting bone density, lipids, or hemoglobin in normal men.

This study found that while testosterone administration reduced myocardial damage in gonadectomized rats after ischemia/reperfusion injury, Finasteride led to greater improvements, whereas 4-hydroxyandrostenedione worsened outcomes.

This study found that administering lycopene to rats provided significant protection against the testicular damage caused by finasteride, as indicated by improved sperm parameters, and reduced oxidative stress and apoptosis markers.

This case study reports that in an 8-year-old male, a pituitary adenoma causing isolated high LH secretion led to early testosterone-driven puberty without typical testicular enlargement, highlighting the differential roles of LH and FSH in pubertal development.

In this study, men with persistent sexual dysfunction after stopping finasteride showed significant vascular, neurologic, and hormonal abnormalities, with severe erectile dysfunction being common.

5α-Reductase helps regulate hormone action in toad testes, especially during breeding season.

Testosterone needs to be converted to DHT to reduce stress response in male rats.

This study found that young men using finasteride for androgenic alopecia experienced erectile dysfunction and signs of erectile tissue fibrosis, alongside symptoms like low libido and mood changes.

In this study, three cases of young men using finasteride for five years showed altered sperm morphology and motility issues, with partial improvement observed after discontinuation.

This study found that chronic administration of dutasteride in rats did not affect spermatogenesis or oxidative stress in the testes, although it altered hormone levels.

This review examines the negative effects of anabolic-androgenic steroid use on the male reproductive system, including impaired testosterone production, sperm production issues, and adverse metabolic consequences without reporting new clinical results.

This study concluded that finasteride-induced DHT deficiency intensified constitutive iNOS expression in rat testicular and epididymal cells, suggesting a complex regulatory relationship needing further investigation.

This study found that men experiencing long-term symptoms after finasteride use for androgenetic alopecia frequently reported loss of penis sensitivity and anhedonia, among other effects, indicating potential post-finasteride syndrome.

This case report describes a patient who developed localized hypertrichosis of the pinnae after undergoing orchiectomy and chemotherapy for testicular carcinoma.

This study found that inhibiting the 5alpha-reductase 2 pathway in male rats affects brain sexual differentiation and leads to reproductive changes, including increased pre-implantation loss despite unchanged copulatory potential.

This review concludes that preoperative hormonal stimulation with testosterone or DHT may help increase penile length and glans circumference, easing hypospadias surgery and potentially reducing postoperative complications.

This study found that experimentally induced iodine deficiency in growing male lambs led to hypothyroidism, resulting in stunted growth, reduced wool production, and disrupted sexual maturity.

This chapter reviews the role of the testes in producing and functioning of testicular androgens and protein hormones, but it presents no new clinical results.

This study found that after 12 months of treatment with 5 mg of finasteride, patients with benign prostatic hyperplasia showed reduced prostate volume, DHT and PSA levels, and improved urinary flow rates and symptoms.