Testosterone-Stimulated Weanlings as an Alternative to Castrated Male Rats in the Hershberger Anti-Androgen Assay

March 2004 in “ Regulatory Toxicology and Pharmacology ”

J. Ashby, P.A. Lefevre, H. Tinwell, J. Odum, William Owens

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testosterone propionate Hershberger assay anti-androgens flutamide procymidone vinclozolin DDE testosterone-5-reductase inhibitor finasteride 17-methyltestosterone dihydrotestosterone TP DHT

Studysummary Using testosterone-stimulated weanling rats can effectively replace castrated rats for anti-androgen testing, reducing animal stress.

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