TLDR 5α-Reductase helps regulate hormone action in toad testes, especially during breeding season.
The study investigated the role of the enzyme 5α-reductase (5α-Red) in regulating glucocorticoid (GC) action in the testis of the toad Rhinella arenarum. It was found that 5α-Red activity was localized in the microsomal fraction of testicular cells and played a role in converting testosterone to 5α-dihydrotestosterone (5α-DHT) and progesterone to 5α-pregnan-3,20 dione. The research suggested that 5α-Red could modulate GC action, which is crucial for understanding the physiological effects of seasonal GC rhythms in amphibians. The study highlighted the importance of 5α-Red in the testicular function of R. arenarum, particularly during the breeding season when GC levels are elevated.
46 citations
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September 2011 in “Journal of Endocrinology” Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
219 citations
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October 2009 in “Steroids” 5α-reductase inhibitors, like Finasteride and Dutasteride, help manage benign prostatic hyperplasia.
53 citations
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June 1993 in “Proceedings of the National Academy of Sciences of the United States of America” LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.
46 citations
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September 2011 in “Journal of Endocrinology” Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
31 citations
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January 2017 in “Advances in Experimental Medicine and Biology” Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.
18 citations
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March 2020 in “Frontiers in Neuroendocrinology” The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
101 citations
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April 1994 in “Baillière's clinical endocrinology and metabolism” 5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.
3 citations
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January 2016 in “Elsevier eBooks” Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.
