Anejaculation Caused by Hemosiderosis: Male Infertility in Hereditary Hemochromatosis

A 36-year-old man with hereditary haemochromatosis experienced subfertility due to anejaculation, fatigue, and limited facial hair growth. His condition was confirmed by elevated iron saturation, serum ferritin, and liver enzymes, alongside a homozygous C282Y mutation of the HFE gene. Venesection therapy normalized liver enzymes and reduced ferritin and transferrin levels, but did not normalize luteinizing and follicle-stimulating hormones. Gonadotropin treatment corrected ejaculation and semen characteristics, but his partner only became pregnant after three IVF attempts. The study highlighted the importance of considering haemochromatosis in cases of subfertility linked to endocrine disorders, noting that early diagnosis and treatment are crucial for reversing organ damage. However, advanced disease progression may prevent the restoration of normal reproductive function.