TLDR Testosterone reduces heart damage and inflammation after injury.
The study evaluated the effects of testosterone and its metabolic inhibition on myocardial remodeling in gonadectomized rats after ischemia/reperfusion injury. Testosterone administration reduced myocardial damage, inflammation, and MMP-3 and 13 expressions. Finasteride further decreased scar tissue and inflammation, while 4-hydroxyandrostenedione increased these parameters. The findings suggested that testosterone's effects were not direct, as inhibiting both aromatase and 5α-reductase did not significantly alter myocardial injury.
47 citations,
July 2009 in “Journal of Biological Chemistry” Finasteride helps treat hair loss and prostate enlargement by blocking a specific enzyme.
23 citations,
July 1993 in “Pharmacotherapy” Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.
343 citations,
October 2015 in “Endocrine Practice” The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.
5 citations,
January 2017 in “Endocrinology” Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.
8 citations,
December 2022 in “International journal of molecular sciences” Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.
88 citations,
April 2017 in “Journal of Pediatric and Adolescent Gynecology” The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.
