Inhibition of 5-Alpha Reductase Attenuates Cardiac Oxidative Damage in Obese and Aging Male Rats via the Enhancement of Antioxidants and the p53 Protein Suppression

September 2024 in “ Chemico-Biological Interactions ”

Nattayaporn Apaijai, Hiranya Pintana, Thiraphat Saengmearnuparp, Aphisek Kongkaew, Busarin Arunsak, Titikorn Chunchai, Siriporn C. Chattipakorn, Nipon Chattipakorn

5-alpha reductase Finasteride antioxidants p53 protein oxidative stress DNA fragmentation insulin resistance Propecia

TLDR Finasteride improves heart function in obese and aging male rats by reducing oxidative stress and p53 protein levels.

The study investigated the effects of Finasteride (Fin), a 5-alpha reductase inhibitor, on cardiac function in aging and obese male rats. Fin treatment improved cardiac sympathovagal balance and function by enhancing antioxidant activity and reducing oxidative stress and DNA fragmentation. However, Fin did not affect metabolic disturbances in aging and obese rats but induced insulin resistance in lean rats. The findings suggest that Fin could be a potential alternative for protecting cardiac function in conditions of oxidative damage.

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