Inhibition of 5-Alpha Reductase Attenuates Cardiac Oxidative Damage in Obese and Aging Male Rats via the Enhancement of Antioxidants and the p53 Protein Suppression

    September 2024 in “ Chemico-Biological Interactions ”
    Nattayaporn Apaijai, Hiranya Pintana, Thiraphat Saengmearnuparp … Nipon Chattipakorn
    🚨 The study involves 5-alpha reductase, which is relevant to hair loss treatments, but focuses on cardiac function rather than hair or scalp health.
    Studysummary In this study, researchers observed that Finasteride improved cardiac function by enhancing antioxidant levels and reducing oxidative stress in obese and aging rats, though it did not benefit metabolic status and induced insulin resistance in normal diet-fed rats.
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    Research cited in this study 11

    1. Therapeutic Effect of Finasteride Through Its Antiandrogenic and Antioxidant Role in a Propionic Acid-Induced Autism Model: Demonstrated by Behavioral Tests, Histological Findings and MR Spectroscopy Neuroscience Letters · 2022
    2. Antioxidant and Antiproliferative Activity of Finasteride Against Glioblastoma Cells Pharmaceutics · 2021
    3. Anti-Androgenic Therapy with Finasteride in Patients with Chronic Heart Failure – A Retrospective Propensity Score Based Analysis Scientific Reports · 2019
    4. Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling, and Reverts Pathologic Gene Expression After Myocardial Infarction in Mice Journal of Molecular and Cellular Cardiology · 2018
    5. Exercise Activates the PI3K-AKT Signal Pathway by Decreasing the Expression of 5α-Reductase Type 1 in PCOS Rats Scientific reports · 2018
    6. Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development Archives of Medical Science · 2017
    7. A Herbal Formula, Comprising Panax Ginseng and Bee-Pollen, Inhibits Development of Testosterone-Induced Benign Prostatic Hyperplasia in Male Wistar Rats Saudi Journal of Biological Sciences · 2015
    8. Finasteride Has Regionally Different Effects on Brain Oxidative Stress and Acetylcholinesterase Activity in Acute Thioacetamide-Induced Hepatic Encephalopathy in Rats PLOS ONE · 2015
    9. Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction Circulation · 2015
    10. 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents Diabetes · 2014
    11. Influence of Dosing Time on the Efficacy and Safety of Finasteride in Rats Journal of Pharmacology and Experimental Therapeutics · 2011