Finasteride Has Regionally Different Effects on Brain Oxidative Stress and Acetylcholinesterase Activity in Acute Thioacetamide-Induced Hepatic Encephalopathy in Rats

August 2015 in “ PLOS ONE ”

Dušan Mladenović, Nataša Petronijević, Tanja Stojkovic, Miloš Velimirović, Goran Jevtić, Dragan Hrnčić, Tatjana Radosavljević, Aleksandra Rašić-Marković, Nebojša Maksić, Dragan Djuric, Olivera Stanojlović

finasteride oxidative stress acetylcholinesterase activity hepatic encephalopathy Propecia

Studysummary This study found that finasteride has selective effects on oxidative stress and acetylcholinesterase activity in different brain regions in rats with thioacetamide-induced hepatic encephalopathy.

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The study investigated the effects of finasteride on brain oxidative stress and acetylcholinesterase activity in acute thioacetamide-induced hepatic encephalopathy in rats. The results showed that finasteride had regionally different effects on brain oxidative stress and acetylcholinesterase activity, with some regions showing increased oxidative stress and decreased acetylcholinesterase activity, while others showed the opposite. The study suggests that finasteride may have potential therapeutic effects in hepatic encephalopathy, but further research is needed to fully understand its mechanisms of action.

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