Finasteride Has Regionally Different Effects on Brain Oxidative Stress and Acetylcholinesterase Activity in Acute Thioacetamide-Induced Hepatic Encephalopathy in Rats

    August 2015 in “ PLOS ONE ”
    Dušan Mladenović, Nataša Petronijević, Tanja Stojkovic … Olivera Stanojlović
    Studysummary This study found that finasteride has selective effects on oxidative stress and acetylcholinesterase activity in different brain regions in rats with thioacetamide-induced hepatic encephalopathy.
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    Research cited in this study 7

    1. 5α-Reductase Inhibitors Alter Steroid Metabolism and May Contribute to Insulin Resistance, Diabetes, Metabolic Syndrome, and Vascular Disease: A Medical Hypothesis Hormone Molecular Biology and Clinical Investigation · 2014
    2. Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy American Journal of Physiology-gastrointestinal and Liver Physiology · 2014
    3. Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-Alpha Journal of Neuroendocrinology · 2011
    4. Anti-Nociceptive and Anti-Inflammatory Properties of 5alpha-Reductase Inhibitor Finasteride in Experimental Animals European Journal of Drug Metabolism and Pharmacokinetics · 2008
    5. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    6. Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids Alcohol · 2005
    7. The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches Pharmacology & Therapeutics · 2004