Finasteride Has Regionally Different Effects on Brain Oxidative Stress and Acetylcholinesterase Activity in Acute Thioacetamide-Induced Hepatic Encephalopathy in Rats

August 2015 in “ PLOS ONE ”

Dušan Mladenović, Nataša Petronijević, Tanja Stojkovic, Miloš Velimirović, Goran Jevtić, Dragan Hrnčić, Tatjana Radosavljević, Aleksandra Rašić-Marković, Nebojša Maksić, Dragan Djuric, Olivera Stanojlović

finasteride oxidative stress acetylcholinesterase activity hepatic encephalopathy Propecia

TLDR Finasteride affects brain stress and enzyme activity differently in various regions, possibly helping with liver-related brain issues.

The study investigated the effects of finasteride on brain oxidative stress and acetylcholinesterase activity in acute thioacetamide-induced hepatic encephalopathy in rats. The results showed that finasteride had regionally different effects on brain oxidative stress and acetylcholinesterase activity, with some regions showing increased oxidative stress and decreased acetylcholinesterase activity, while others showed the opposite. The study suggests that finasteride may have potential therapeutic effects in hepatic encephalopathy, but further research is needed to fully understand its mechanisms of action.

View this study on journals.plos.org →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy

17 citations, November 2014 in “American Journal of Physiology-gastrointestinal and Liver Physiology”

Finasteride helps brain function in rats with liver-related brain issues.

5α-Reductase Inhibitors Alter Steroid Metabolism and May Contribute to Insulin Resistance, Diabetes, Metabolic Syndrome, and Vascular Disease: A Medical Hypothesis

research 5α-Reductase Inhibitors Alter Steroid Metabolism and May Contribute to Insulin Resistance, Diabetes, Metabolic Syndrome, and Vascular Disease: A Medical Hypothesis

15 citations, October 2014 in “Hormone Molecular Biology and Clinical Investigation”

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

61 citations, September 2008 in “Biological & Pharmaceutical Bulletin”

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

research Anti-Nociceptive and Anti-Inflammatory Properties of 5alpha-Reductase Inhibitor Finasteride in Experimental Animals

11 citations, July 2008 in “European Journal of Drug Metabolism and Pharmacokinetics”

Finasteride helps reduce pain and inflammation in animals.

Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

research Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

54 citations, August 2005 in “Alcohol”

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Related Community Posts Join

6 / 1000+ results

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 6 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community 3 month progress pictures RU fin and OM

in Progress Pictures 42 upvotes 1 year ago

The user shared progress pictures after three months of using RU58841, finasteride, and OM (oxidative stress modulators) for hair loss treatment. They haven't noticed much change but are seeking feedback on their results.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 2 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community Interested about what other adjunct therapies people are trying & whats working?

in Treatment 8 upvotes 8 months ago

The conversation discusses alternative hair loss treatments beyond the commonly used Minoxidil and Finasteride. One user is trying diclofenac gel, caffeine + antioxidant serum, finasteride, ketoconazole shampoo, and has stopped using Minoxidil due to ineffectiveness, while another user has adopted lifestyle changes like exercise, diet, stress reduction, and topical caffeine, along with scalp massages and microneedling.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 411 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community For what it's worth, I just want to state that I also think that adding Dutasteride to Finasteride has made my hair worse

in Finasteride/Dutasteride 19 upvotes 3 years ago

A user shared that adding Dutasteride to Finasteride worsened their hair loss, despite initial improvements with Finasteride alone. Others in the conversation debated the effectiveness of Dutasteride, with some suggesting individual responses vary and others defending its proven efficacy for hair loss.

Similar Research

5 / 1000+ results

research The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats

14 citations, March 2018 in “Translational Stroke Research”

Finasteride helps protect brain in old male rats.

research Finasteride Promotes Worsening of the Cardiac Deleterious Effects of Nandrolone Decanoate and Protects Against Genotoxic and Cytotoxic Damage

January 2020 in “Brazilian Journal of Pharmaceutical Sciences”

Finasteride worsens heart damage from nandrolone decanoate but protects against cell damage.

The Potential Involvement of Cholinergic System in Finasteride Induced Cognitive Dysfunction