Finasteride Has Regionally Different Effects on Brain Oxidative Stress and Acetylcholinesterase Activity in Acute Thioacetamide-Induced Hepatic Encephalopathy in Rats
August 2015
in “
PLOS ONE
”
TLDR Finasteride affects brain stress and enzyme activity differently in various regions, possibly helping with liver-related brain issues.
The study investigated the effects of finasteride on brain oxidative stress and acetylcholinesterase activity in acute thioacetamide-induced hepatic encephalopathy in rats. The results showed that finasteride had regionally different effects on brain oxidative stress and acetylcholinesterase activity, with some regions showing increased oxidative stress and decreased acetylcholinesterase activity, while others showed the opposite. The study suggests that finasteride may have potential therapeutic effects in hepatic encephalopathy, but further research is needed to fully understand its mechanisms of action.
