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breaks down acetylcholine in the synaptic cleft

Acetylcholinesterase (AChE) is an enzyme that breaks down the neurotransmitter acetylcholine in the synaptic cleft, which is the space between nerve cells. This process is crucial for terminating nerve impulses and allowing muscles to relax after contraction. Inhibiting AChE can lead to prolonged muscle contraction and is a mechanism used by certain nerve agents and pesticides.