Finasteride Promotes Worsening of the Cardiac Deleterious Effects of Nandrolone Decanoate and Protects Against Genotoxic and Cytotoxic Damage

    January 2020 in “ Brazilian Journal of Pharmaceutical Sciences ”
    Elizangela Faustino da Mata, Andrews Marques do Nascimento, Ewelyne Miranda de Lima, Ieda Carneiro Kalil, Denise Coutinho Endringer, Dominik Lenz, Nazaré Souza Bissoli, Girlandia Alexandre Brasil, Tadeu Uggere de Andrade
    TLDR Finasteride worsens heart damage from nandrolone decanoate but protects against cell damage.
    The study concluded that finasteride exacerbated the harmful cardiac effects of nandrolone decanoate (ND), such as hypertrophy, inflammation, and increased ACE activity, while providing protection against genotoxic and cytotoxic damage in male Wistar rats. This dual effect highlighted the complex interactions between these substances, suggesting that while finasteride might mitigate some cellular damage, it could also worsen cardiovascular outcomes when combined with anabolic steroids like ND.
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