Preoperative Hormonal Stimulation in Hypospadias: A Systematic Review

January 2023 in “ The Annals of african surgery ”

Indrayudha Pramono, Safendra Siregar, Jupiter Sibarani

testosterone dihydrotestosterone DHT neovascularization

TLDR Hormone treatment before hypospadias surgery can increase penis size and reduce surgery complications.

The systematic review and meta-regression analysis, which included 15 relevant articles published between 2000 and 2020, found that preoperative hormonal stimulation with testosterone or dihydrotestosterone (DHT) is commonly used in the treatment of hypospadias. This treatment is associated with increased penile length and glans circumference, which may facilitate the surgical reconstruction process. Additionally, the use of testosterone and DHT was found to enhance neovascularization and reduce the risk of postoperative complications. The hormones were administered in various forms, with testosterone being given topically, parenterally, or orally, and DHT primarily used topically.

View this study on ajol.info →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

76 citations, August 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

research Testosterone Prevents Cutaneous Ischemia and Necrosis in Males Through Complementary Estrogenic and Androgenic Actions

12 citations, March 2017 in “Arteriosclerosis, thrombosis, and vascular biology”

Testosterone helps prevent skin damage in males by acting through both estrogen and androgen pathways.

Oral and Topical Administration of Standardized Saw Palmetto Oil Reduces Hair Fall and Improves Hair Growth in Androgenetic Alopecia Subjects: A 16-Week Randomized, Placebo-Controlled Study

research Oral and Topical Administration of Standardized Saw Palmetto Oil Reduces Hair Fall and Improves Hair Growth in Androgenetic Alopecia Subjects: A 16-Week Randomized, Placebo-Controlled Study

November 2023 in “Clinical, Cosmetic and Investigational Dermatology”

Saw palmetto extract reduced hair loss and improved hair growth in people with hair thinning.

research Cell-Free Fat Extract Restores Hair Loss: A Novel Therapeutic Strategy for Androgenetic Alopecia

August 2023 in “Stem Cell Research & Therapy”

A substance called Cell-free fat extract can effectively treat common hair loss by increasing hair growth and density.

research Current Understanding and Treatment of Sex Hormone-Related Hair Diseases

April 2023 in “Dermatologica Sinica”

Sex hormones affect hair growth and loss, and treatments for related hair diseases include various medications, hair transplantation, and light therapy.

Preoperative Hormonal Stimulation in Hypospadias: A Systematic Review

Related Community Posts Join

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

community 3 months of minoxidil foam. No fin or derma rolling

community 6 months of microneedling, minox, 1% keto, & biotin. Time for fin?

community So excited! Just got dutasteride for free when I forever thought I’d have to pay! 😭

community Received Kintor’s KX-826 Today