Pathological and Biochemical Studies on Experimental Hypothyroidism in Growing Lambs

    November 2000 in “ Journal of Veterinary Medicine Series B ”
    S. M. Sokkar, Ashraf H. Soror, Youssef Ahmed, Omaima H. Ezzo, M. A. Hamouda
    TLDR Iodine deficiency in lambs causes poor growth, less wool, and delayed sexual maturity.
    In this study, secondary iodine deficiency was induced in growing male lambs through the administration of Thiourea, leading to hypothyroidism. Over 3.5 months, the lambs exhibited weakness, emaciation, anemia, reduced body weight, facial edema, and alopecia. Clinical analysis showed decreased erythrocyte and leucocyte counts, and lower levels of triiodothyronine and testosterone. Pathological findings included thyroid gland hyperplasia, underdeveloped testes, liver degeneration, and kidney glomerular lipidosis. The study concluded that iodine deficiency caused growth retardation, reduced wool production, and affected sexual maturity in the lambs.
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