Pathological and Biochemical Studies on Experimental Hypothyroidism in Growing Lambs

In this study, secondary iodine deficiency was induced in growing male lambs through daily administration of Thiourea, resulting in hypothyroidism. After 3.5 months, the lambs exhibited weakness, emaciation, anemia, reduced body weight, facial edema, and alopecia. Clinical analysis showed decreased erythrocyte and leucocyte counts, and lower levels of triiodothyronine and testosterone. Histopathological examination revealed thyroid gland hyperplasia, underdeveloped testes, liver degeneration, and kidney lipidosis. Additionally, hyperkeratosis and excessive keratin formation in hair follicles were observed. The study concluded that iodine deficiency led to growth retardation, reduced wool production, and impaired sexual maturity in the lambs.