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Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

The Brazilian Society of Dermatology agrees that oral isotretinoin is effective for acne and other skin conditions, and it's safe when monitored, but more research is needed on dosing and duration.

New treatments for skin conditions related to the sebaceous gland are being developed based on current research.

Thyroid problems are linked to various skin issues, and checking thyroid health is important for people with certain skin conditions.

Isotretinoin may cause temporary, reversible facial hair growth in some women.

Topical retinoids effectively improve photodamaged skin.

Targeted anticancer therapies can cause severe side effects similar to traditional chemotherapy, but with different types.

Vitamin A affects hair loss and immune response in alopecia areata.

Vitamin D might help regulate insulin in the body, but taking Vitamin D supplements doesn't clearly prevent or improve type 2 diabetes. More research is needed.

Retinoids are effective for various skin conditions and hair loss but have serious side effects, so low doses are recommended.

Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.

Alitretinoin may help treat alopecia areata.

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

Retinoids or their analogs could treat skin pigmentation disorders like melasma and vitiligo.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

A specific drug can help treat Lichen Planopilaris, a condition causing permanent hair loss.

PPAR-γ helps control skin oil glands and inflammation, and its disruption can cause hair loss diseases.

Noncoding dsRNA boosts hair growth by activating TLR3 and increasing retinoic acid.

Increased PPARGC1α relates to hair thinning in common baldness.

Lithocholic acid helps hair growth and regeneration in alopecia by activating vitamin D receptors.

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

Retinoic acid affects skin and hair health by working with specific receptors, and its absence can lead to hair loss and skin changes.

Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.

PPAR-γ is important for healthy hair and its problems, and more research on PPAR-γ treatments is needed.

As skin cells mature, vitamin D receptor levels decrease while retinoid X receptor α levels increase.