Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin

The document reviewed the therapeutic mechanisms of topical retinoids in treating photodamaged skin, highlighting studies that demonstrated the efficacy and safety of retinoids like tretinoin, adapalene, and tazarotene. These studies, including randomized controlled trials, showed significant improvements in skin texture, elasticity, and collagen production. The document also discussed the molecular pathways of retinoids, including the regulation of retinoid-mediated signaling and suppression of negative regulators of collagen homeostasis. Additionally, advancements in drug delivery systems, such as lipid-based and polymer-based nanocarriers, were noted for enhancing the absorption and stability of retinoids. Overall, the evidence supported the use of topical retinoids as effective treatments for photodamaged skin.