17 citations
,
January 2015 in “MedChemComm” New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.
13 citations
,
January 2021 in “Scientific Reports” This study found that Pannexin 3 plays a crucial role in skin development by regulating the transcription factor Epiprofin, affecting keratinocyte differentiation and hair follicle regeneration in mice.
6 citations
,
June 2017 in “Asian journal of beauty & cosmetology” In this study, Rosa multiflora root extracts showed strong antioxidant activity and promoted expression of growth factors IGF1 and PDGFB, suggesting potential use as a natural hair growth agent.
2 citations
,
January 2025 in “Pharmaceutical Research” This article reviews the possible therapeutic activities of Angelica gigas Nakai root extracts and their components, noting their potential effects on neuro-cognitive, metabolic, and other health conditions, and reports no new clinical results.
2 citations
,
January 2023 in “International journal of biological sciences” This review discusses the mechanisms of hair repigmentation and reports no clinical results; the authors suggest further research into topical treatments for reversing gray hair.
2 citations
,
June 2022 in “The Bulletin of Contemporary Clinical Medicine” This study suggests that although hydroxyapatite gel has strong bactericidal effects, its combination with platelet-enriched blood autoplasm does not enhance antibacterial activity in endodontic treatment for chronic apical periodontitis.
2 citations
,
April 2019 in “Experimental Dermatology” The article concludes that studying how skin forms is key to understanding skin diseases and improving regenerative medicine.
1 citations
,
January 2018 in “Stem cell biology and regenerative medicine” This review discusses the roles of DNA methylation in skin development and regeneration, highlighting its impact on embryonic skin lineage, homeostasis, and potential therapeutic targets, but reports no new clinical results.
This study reported that pentoxifylline-loaded liposomes, optimized using a statistical design method, achieved a maximum encapsulation efficiency of 84.23% and a controlled 72-hour drug release, potentially improving therapeutic delivery of the drug with limited bioavailability.
December 2025 in “Italian Journal of Anatomy and Embryology” This narrative literature review examined how linking embryonic development with non-genetic skin anomalies can improve diagnostic accuracy, guide prenatal counseling, and enrich dermatology education by revealing specific vulnerabilities in skin morphogenesis and supporting advances in regenerative medicine.
November 2025 in “Frontiers in Immunology” This review integrates studies on mouse models and human clinical observations to highlight the role of immune cells in skin development and how their dysregulation leads to skin disorders, suggesting potential therapeutic pathways for skin regeneration.
April 2024 in “Frontiers in physiology” This review article examines recent studies on the role of diverse immune cells in forming an active niche for hair follicles, offering new insights into hair growth and related diseases.
September 2023 in “Medical lasers” In this study, using a shampoo with Morus alba root extract over 12 weeks increased hair density and shaft thickness in patients with mild to moderate non-scarring alopecia, with both investigators and participants noting visible improvements and moderate satisfaction.
June 2023 in “Livestock studies” This review highlights the significance of animal fibers, examining the molecular mechanisms influencing hair follicle development and their impact on fiber quality and quantity, with a focus on studies involving Angora and cashmere goats.
October 2022 in “International journal of research and review” This case report suggests that intracanal medication with calcium hydroxide paste may alleviate colitis symptoms triggered by Formacresol used during dental retreatment in a 46-year-old patient.
April 2016 in “Journal of Investigative Dermatology” This study found that topical phenylephrine, an α1-AR agonist, significantly reduced hair shedding and increased epilation force threshold in women experiencing traction alopecia during cosmetic procedures.
This study found that an Ayurveda-based regimen including Guduchi, Ashwagandha, and Curcumin may improve quality of life and safely reduce symptoms in breast cancer patients undergoing conventional therapy.
27 citations
,
April 2020 in “Journal of Experimental Botany” This study found that glutathione deficiency affects lateral root and root hair responses to indole butyric acid in plants, but not to indole acetic acid, indicating its role in auxin pathway regulation.
1 citations
,
July 2023 in “Horticulture research” In this review, the authors explored how epigenetic regulation influences the development of plant trichomes, highlighting the significant role of microRNA-mediated post-transcriptional regulation and suggesting new research avenues in plant epigenetics.
December 2017 in “International Journal of Current Research in Biosciences and Plant Biology” This paper discusses how various nutrients and phytohormones affect root hair growth and suggests further research to understand the genetic and signaling mechanisms involved, but it reports no new experimental findings.
184 citations
,
September 2006 in “PLoS Genetics” This study found that loss of Apc due to K14-cre-mediated gene recombination in mice led to aberrant growth in ectodermally derived squamous epithelia, implicating its critical role in specifying epithelial cell fates during embryonic development.
88 citations
,
January 2004 in “Journal of Neuroscience” This study found that inhibiting neurosteroidogenesis affected GABA A receptor-mediated synaptic inhibition in immature rats but not in adults, suggesting age-dependent modulation of synaptic strength in the spinal dorsal horn.
60 citations
,
September 2015 in “Expert Review of Clinical Immunology” This study suggests that CD8+ cytotoxic T lymphocytes play a crucial role in the development of alopecia areata, based on observations in rodent models that mimic human autoimmune disease.
19 citations
,
June 2020 in “Animals” This study found that maternal sub-maintenance nutrition reduced the density and branching ratio of secondary wool follicles in Merino sheep fetuses and identified genes potentially involved in these processes.
19 citations
,
July 2015 in “Journal of Ginseng Research” In this study, Korean Red Ginseng showed protective effects against chemotherapy-induced premature hair follicle aging in an in vitro model by modulating specific cellular protein expressions.
9 citations
,
July 2020 in “Journal of Animal Physiology and Animal Nutrition” This study found that maternal melatonin supplementation improved fur quality in Rex rabbit offspring by increasing hair follicle density and altering melatonin receptor gene expression in several organs.
4 citations
,
February 2021 in “Nano select” This review discusses the role and therapeutic potential of mesenchymal cell-derived exosomes in organ development and disease treatment, highlighting their application in cell-free therapeutic strategies and current challenges faced in their use.
4 citations
,
March 2014 in “The FASEB Journal” This study observed that deleting ARNT in keratinocytes of mice reduced zigzag hair production and altered hair follicle differentiation, likely by affecting the expression of specific cyclin-dependent kinase inhibitors.
3 citations
,
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study revealed key cellular dynamics and interactions during early embryonic mouse skin development, highlighting complex transitions from precursor states to diverse multilayered structures.
2 citations
,
December 2022 in “Scientific Data” This study used single-cell ATAC sequencing to map chromatin accessibility in developing mouse hair follicles, offering insights into the transcriptional regulation and epigenetic mechanisms underlying hair follicle development.