Efficacy and Safety of a Botanical Shampoo Containing Morus Alba Root Extract in Republic of Korea: A Single-Center, Open-Label, Pilot Study in Mild to Moderate Non-Scarring Alopecia of the Scalp

This single-center, open-label pilot study evaluated the efficacy and safety of a botanical shampoo containing Morus alba root extract (MARE) in 20 patients with mild to moderate non-scarring alopecia over 12 weeks. Significant improvements were observed in hair density and hair shaft thickness, with the average hair diameter increasing from 50.83 ± 8.97 µm to 55.56 ± 9.31 µm in the vertex and from 60.06 ± 9.84 µm to 64.56 ± 6.79 µm in the occiput. Blinded investigators reported moderate improvements in alopecia, and participants expressed moderate satisfaction with the results. No significant adverse events were reported, indicating that the MARE shampoo is a safe and effective treatment for hair loss. Further research with larger sample sizes and controlled groups is recommended.