research 688 Precise and efficient editing of the COL7A1 gene in RDEB derived iPSCs with CRISPR/Cas9 and prime editing
CRISPR/Cas9 and prime editing can potentially fix skin disorder genes safely and effectively.
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research Functional mapping of the mouse hairless gene promoter region
This study identified a new cis-regulatory element in the mouse Hr gene that influences its expression in skin and brain cells, highlighting a complex molecular network involved in hair follicle formation.
research Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways
In this study, researchers overexpressed Lrig3 in mouse skin and observed hair loss linked to changes in skin protein profiles and signaling pathways, suggesting a potential role for Lrig3 in maintaining skin homeostasis.
research PRP for androgenetic alopecia
research Application of Autologous Concentrated Growth Factor (CGF) in Treating Androgenetic Alopecia (AGA): 20 Cases
research Nerve growth factor regulates the proliferation of cashmere goat outer root sheath cells through the activation of cAMP-binding protein
This study suggests that the NGF/TrkA/CREB system plays a crucial role in promoting outer root sheath cell proliferation in cashmere goats, which may aid in marker-assisted breeding.
research Ginsenosides Rb1 and Rd Regulate Proliferation of Mature Keratinocytes Through Induction of p63 Expression in Hair Follicles
In this study, topical application of ginsenosides Rb₁ and Rd in mice increased cell proliferation in hair follicles, suggesting they may help prevent hair loss by promoting growth through p63 induction.
research RE-ORGA, a Korean Herb Extract, Can Prevent Hair Loss Induced by Dihydrotestosterone in Human Dermal Papilla Cells
In this study, researchers observed that RE-ORGA, a preparation from Korean herbs, may help alleviate androgenic alopecia by promoting human dermal papilla cell proliferation, reducing 5α-reductase enzyme levels, and displaying anti-inflammatory properties, suggesting potential regulation of androgen receptor sensitivity.
research Association of Autoimmune Regulator Gene Rs2075876 Variant, but Not Gene Expression with Alopecia Areata in Males: A Case–control Study
This study suggests that the rs2075876 variant in the AIRE gene may significantly increase susceptibility to alopecia areata in the examined male population.
research Epidermal growth factor in aesthetics and regenerative medicine: Systematic review
This systematic review describes current findings on the use of recombinant epidermal growth factor (rhEGF) for skin aging and wound healing, emphasizing its potential benefits but highlighting the need for more controlled studies to optimize dosing and treatment protocols.
research Strontium Ranelate Promotes Chondrogenesis Through Inhibition of the Wnt/β-catenin Pathway
This study found that strontium ranelate may promote cartilage regeneration by enhancing chondrogenic differentiation and inhibiting the Wnt/β-catenin signaling pathway in rat models of cartilage defects.
research Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair
In this in vitro study, red ginseng extract and its main ginsenoside, G-Rb1, were found to protect human hair follicular keratinocytes from oxidative damage, preventing apoptosis, promoting hair growth, and modulating hair cycle transitions by influencing specific cellular signaling pathways.
research Mrp4, A New Mitogen-Regulated Protein/Proliferin Gene; Unique in this Gene Family for its Expression in the Adult Mouse Tail and Ear1
This study identified a new gene, mrp4, in mice, which suggests it may have a unique role in the growth and development of hair follicles in the ears and tails.
research A Case of Rhupus with Rowell Syndrome
This case report describes a 30-year-old woman diagnosed with both Rhupus and Rowell syndromes, and details her presentation and treatment plan, without reporting specific treatment outcomes.
research P167 : Protective effect of Korean Red Ginseng on the chemotherapy induced alopecia
This study found that Korean Red Ginseng may protect against chemotherapy-induced alopecia by reducing hair follicle damage in a human hair follicle organ culture model.
research Research on Expression of Retinoid-related Orphan Receptor (ROR) in the Skin of Cashmere Goat
This study suggests that RORα, RORβ, and RORγ mRNA expression in cashmere goat skin is related to different stages of hair follicle development, indicating a possible role in cycled cashmere growth.
research Rapp-Hodgkin syndrome: A review of the aspects of hair and hair color
This study reported that Rapp-Hodgkin syndrome, AEC syndrome, and EEC syndrome are likely part of a single genetic disorder spectrum linked to mutations in the TP63 gene.
research Real-world study of adverse events associated with gepant use in migraine treatment based on the VigiAccess and U.S. Food and Drug Administration’s adverse event reporting system databases
Gepant medications for migraines show varied safety profiles in this study, with specific adverse events reported across systems like gastrointestinal and skin disorders, highlighting the need for tailored treatment and monitoring.
research Efficacy and Safety of an Autologous Micrografting Procedure for Management of Striae Distensae in Women
The study found that a single autologous micrografting treatment using Rigenera® technology significantly improved the appearance of stretch marks in healthy women after three months, showing greater enhancements in skin properties compared to microneedling alone.
research Evaluation of Efficacy of Water-Soluble Fraction of Rhus semialata Gall Extract and Penta-O-Galloyl-β-D-Glucose on Mitigation of Hair Loss: An In Vitro and Randomized Double-Blind Placebo-Controlled Clinical Study
In this study, the researchers found that the water-soluble fraction of Rhus semialata gall extract and its component Penta-O-Galloyl-β-D-Glucose promoted hair growth in human dermal papilla cells, and clinical trials supported these findings, showing improved hair density and appearance compared to placebo.
research Combination Of Regulatory T Cells and Rapamycin As Treatment For Experimental Chronic Graft-Versus-Host Disease
The study found that the combined administration of regulatory T cells and rapamycin improved outcomes in an experimental model of chronic graft-versus-host disease.
research Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades
In this study, researchers found that ginsenoside Re from Panax ginseng increased hair shaft length and duration in mice, comparable to minoxidil, by modulating TGF-β signaling pathways.
research Ablative 2940-nm Er: YAG fractional laser for the treatment of male androgenetic alopecia with predominantly frontal hairline recession
This study suggests that the PPP2R3C gene may confer susceptibility to psoriatic arthritis and psoriasis vulgaris in Chinese patients, with additional possible associations involving IL-23R, ERN1, IFIH1, and KIF3A genes.
research Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network
This study identifies specific molecular components involved in the intracellular trafficking of LGR5, revealing mechanisms that differ from typical GPCR recycling processes.
research A homozygous nonsense mutation identified in COL7A1 in a family with autosomal recessive dystrophic epidermolysis bullosa
In this study, researchers identified a recurrent nonsense mutation, c.409C>T (p.Arg137*), in the COL7A1 gene through whole exome sequencing in a family with autosomal recessive dystrophic epidermolysis bullosa, demonstrating the importance of this method for diagnosing genetically complex conditions.
research Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes
In this study, PGD2 was shown to increase testosterone production in human keratinocytes through reactive oxygen species, suggesting potential benefits of antioxidants like N-acetyl-cysteine for AGA patients.
research SOVEREIGN PROJECT RE-GENESIS: CONTINUOUS-WAVE PHONOPHORETIC QUANTUM-VOLUMETRIC REGENERATION SYSTEM (CQ-VRS)
This research outlines an innovative bioregeneration chamber aimed at significantly extending human lifespan and enhancing health maintenance by treating the body as a thermodynamic system, potentially enabling an average lifespan of 130 to 150 years in an advanced therapeutic setting.
research Nanotechnology Approaches in Chronic Wound Healing
This review discusses recent advancements in nanotechnology-based treatments for chronic wound healing in diabetic models, noting that despite promising results, these innovations have yet to translate into widely available commercial products.
research Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications
This review discusses the unique properties, design, and fabrication of peptide hydrogels for biomedical applications, focusing on advances in drug delivery, gene therapy, and regenerative medicine; it reports no new clinical results.
research Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury
This study reports that sebaceous glands can regenerate after injury through stem cell plasticity, with hair-follicle-derived stem cells replacing sebaceous gland progenitors and playing a crucial role in the regeneration process, which is dependent on FGFR2 signaling and aided by hair growth induction.