Strontium Ranelate Promotes Chondrogenesis Through Inhibition of the Wnt/β-Catenin Pathway

The study investigated the effects of strontium ranelate (SrR) on chondrogenesis and cartilage regeneration, particularly in the context of temporomandibular joint osteoarthritis (TMJ-OA). Using bone mesenchymal stem cells (BMSCs) from Sprague–Dawley rats, the research demonstrated that SrR at a concentration of 0.25 mmol/L enhanced chondrogenesis without inhibiting cell proliferation. The study found that SrR promoted chondrogenic differentiation by inhibiting the Wnt/β-catenin signaling pathway. In vivo experiments with 30 male SD rats showed that SrR-loaded GelMA significantly improved cartilage regeneration in femoral condyle defects compared to other treatments. The findings suggested that SrR could be a potential therapeutic agent for cartilage regeneration by modulating specific signaling pathways.