A Case of Rhupus with Rowell Syndrome

This document reported a case of a 30-year-old female diagnosed with Rhupus syndrome, characterized by symptoms such as hair loss, photosensitive malar rash, morning stiffness, and synovitis. After initial treatment with hydroxychloroquine, esomeprazole, and azathioprine, and discontinuation of methotrexate due to pill-induced esophagitis, she developed a generalized maculopapular rash. Laboratory tests showed positive anti-double stranded-DNA, anti-nuclear antibody, anti-Ro/SSA, and anti-La/SSB, with low complement levels, leading to a diagnosis of Rowell syndrome. Management included hydroxychloroquine, prednisolone, mycophenolate mofetil, and topical agents, with esomeprazole discontinued. The document also reviewed the management of Rowell syndrome in the literature.