Nerve Growth Factor Regulates the Proliferation of Cashmere Goat Outer Root Sheath Cells Through the Activation of cAMP-Binding Protein

July 2019 in “ Small ruminant research ”

Chunqiang Wang, Yonghua Liu, Wei Ma

nerve growth factor NGF outer root sheath cells ORSCs TrkA pathway cAMP-binding protein CREB proliferation-associated protein PCNA

TLDR Nerve growth factor helps cashmere goat hair cells grow by activating a specific protein.

The study demonstrated that outer root sheath cells (ORSCs) from cashmere goats could sustain the secretion of nerve growth factor (NGF) and that the NGF/TrkA pathway influenced the activity of the transcription factor CREB, leading to the expression of the proliferation-associated protein PCNA. This finding provided a theoretical basis for marker-assisted breeding of cashmere goats to enhance hair growth. The research was supported by several Chinese national foundations and programs, and the authors declared no competing interests.

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