Nerve Growth Factor Regulates the Proliferation of Cashmere Goat Outer Root Sheath Cells Through the Activation of cAMP-Binding Protein

July 2019 in “ Small ruminant research ”

Chunqiang Wang, Yonghua Liu, Wei Ma

nerve growth factor NGF outer root sheath cells ORSCs TrkA pathway cAMP-binding protein CREB proliferation-associated protein PCNA

TLDR Nerve growth factor helps cashmere goat hair cells grow by activating a specific protein.

The study demonstrated that outer root sheath cells (ORSCs) from cashmere goats could sustain the secretion of nerve growth factor (NGF) and that the NGF/TrkA pathway influenced the activity of the transcription factor CREB, leading to the expression of the proliferation-associated protein PCNA. This finding provided a theoretical basis for marker-assisted breeding of cashmere goats to enhance hair growth. The research was supported by several Chinese national foundations and programs, and the authors declared no competing interests.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Expression of Nerve Growth Factor in Skin Tissues and Its Effect on the Proliferation of Outer Root Sheath Cells in Cashmere Goats

1 citations , July 2016 in “Livestock science”

Nerve growth factor helps cashmere goat hair cells grow and is more active during the hair growth phase.

research VEGF Upregulates VEGF Receptor-2 on Human Outer Root Sheath Cells and Stimulates Proliferation Through ERK Pathway

23 citations , June 2012 in “Molecular Biology Reports”

VEGF stimulates hair cell growth and increases growth receptor levels through a specific signaling pathway.

Related Community Posts Join

6 / 140 results

community BPC-157 and Angiogenesis. Bro-Science-Execution-Plan

in Research/Science 13 upvotes 7 months ago

BPC-157 may promote hair growth by increasing angiogenesis, similar to how Minoxidil works, though no direct research confirms this yet. Users report combining BPC-157 with Minoxidil and finasteride for better results, but concerns about long-term safety exist.

community The theory that explains everything. Please help me make this big!

in Research/Science 2446 upvotes 4 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Treatment of Finasteride Induced Gynecomastia (Male breast tissue growth)

in Finasteride/Dutasteride 15 upvotes 5 years ago

Finasteride can cause gynecomastia, which may be reversible by stopping the drug and using selective estrogen receptor modulators (SERMs) like tamoxifen. Lifestyle changes such as weight loss and avoiding alcohol can also help, but surgery may be needed if the condition persists.

community Please explain this Minoxidil phenomena

in Minoxidil 58 upvotes 2 years ago

The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

community Ultimate Stack without nuking your gender (you'll go broke)

in Treatment 81 upvotes 1 year ago

A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hair growth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.

Related Research

5 / 5 results

research Proteomics Analysis of the Secondary Hair Follicle Cycle in Liaoning Cashmere Goat

5 citations , May 2021 in “Small ruminant research”

The study found specific proteins that could mark different growth stages of cashmere goat hair and may help improve cashmere production.

10× Genomics Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

research 10× Genomics Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

1 citations , November 2020 in “Research Square (Research Square)”

The study found specific skin cells and genes that may affect the quality of cashmere in Liaoning Cashmere Goats.

research Expression of Vimentin in Hair Follicle Growth Cycle of Inner Mongolian Cashmere Goats

23 citations , January 2018 in “BMC genomics”

Vimentin is involved in regulating the hair growth cycle in Inner Mongolian Cashmere goats.

research Expression of Nerve Growth Factor in Skin Tissues and Its Effect on the Proliferation of Outer Root Sheath Cells in Cashmere Goats

1 citations , July 2016 in “Livestock science”

Nerve growth factor helps cashmere goat hair cells grow and is more active during the hair growth phase.

research Cloning Without Tears

1 citations , April 1983 in “Trends in Biochemical Sciences”