Nerve Growth Factor Regulates the Proliferation of Cashmere Goat Outer Root Sheath Cells Through the Activation of cAMP-Binding Protein

July 2019 in “ Small ruminant research ”

Chunqiang Wang, Yonghua Liu, Wei Ma

nerve growth factor NGF outer root sheath cells ORSCs TrkA pathway cAMP-binding protein CREB proliferation-associated protein PCNA

Studysummary This study suggests that the NGF/TrkA/CREB system plays a crucial role in promoting outer root sheath cell proliferation in cashmere goats, which may aid in marker-assisted breeding. Our plain-language summary of this paper — not a Tressless recommendation.

The study demonstrated that outer root sheath cells (ORSCs) from cashmere goats could sustain the secretion of nerve growth factor (NGF) and that the NGF/TrkA pathway influenced the activity of the transcription factor CREB, leading to the expression of the proliferation-associated protein PCNA. This finding provided a theoretical basis for marker-assisted breeding of cashmere goats to enhance hair growth. The research was supported by several Chinese national foundations and programs, and the authors declared no competing interests.

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research Expression of Nerve Growth Factor in Skin Tissues and Its Effect on the Proliferation of Outer Root Sheath Cells in Cashmere Goats

1 citations , July 2016 in “Livestock science”

This study suggests that nerve growth factor may support hair follicle growth in Liaoning cashmere goats through pathways involving its receptor, TrkA, particularly during the anagen phase.

research VEGF Upregulates VEGF Receptor-2 on Human Outer Root Sheath Cells and Stimulates Proliferation Through ERK Pathway

23 citations , June 2012 in “Molecular Biology Reports”

This study found that human outer root sheath cells express VEGF receptor-2, and exogenous VEGF165 significantly stimulates their proliferation through activation of the ERK signaling pathway.