January 2018 in “Stem cells in clinical applications” This review discusses the potential of exosomes and the secretome in stem cell-based regenerative therapies but reports no new experimental findings.
September 2013 in “Molecular Biology” This study found that Satura Rosta Balm exerts a cytotoxic effect under oxidative stress and may trigger regeneration through autophagic pathways, despite not promoting proliferation or stress resistance in human cells.
January 2012 in “Elsevier eBooks” This chapter reviews therapies for skin and corneal regeneration and hair loss, discussing various treatments but presenting no new research findings.
June 2026 in “International Science Journal” This study reviewed recent advances in regenerative technologies for aesthetic and reconstructive medicine and found that adipose-derived stem cells and platelet-rich plasma are well-established for tissue repair due to their safety and effectiveness, while emerging technologies like exosome-based therapies hold future potential.
This study found that Fraser's Dolphin, a tight-skinned mammal, can regenerate complex skin architecture with minimal scarring after large full-thickness wounds, even in high-tension environments, offering insights into regenerative healing mechanisms typically obscured by fibrotic responses.
August 2024 in “Life Science Alliance” This study found that topical application of TGF-β mimic promoted enhanced wound healing and tissue regeneration in mice, suggesting its potential as a therapeutic option for improving wound healing.
This dissertation reported that the loss of Ovol2 impairs hair follicle regeneration and wound repair in mice, highlighting its role in regulating directional migration of epithelial cells.
162 citations
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July 2011 in “Biomacromolecules” This study found that chitosan nanofibrillar scaffolds accelerated skin wound healing in mice by enhancing cell adhesion, proliferation, and regeneration of epidermis and dermis compared to other forms.
March 2024 in “Research Square (Research Square)” In this study, researchers found that the protein Twist2 plays a crucial role in scarless wound healing in early embryonic mouse skins, with its knockdown leading to visible scarring and defective hair follicle formation, suggesting potential therapeutic targets for reducing scars and promoting regeneration.
41 citations
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September 2011 in “Journal of Ethnopharmacology” This study indicates that Fructus panax ginseng extract may promote hair growth by increasing proliferation in human hair dermal papilla cells and lengthening the anagen phase in mice.
408 citations
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January 2017 in “Science” This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.
6 citations
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November 2013 in “International Journal of Radiation Biology” In this study, γ-ray irradiation of mice reduced hair follicle density and pigmentation, suggesting damage to stem cells and progenitors for keratinocytes and melanocytes.
2 citations
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April 2009 in “Bulletin of Experimental Biology and Medicine” Flamena, a liposomal mix, helps skin heal better after a chemical burn.
December 2012 in “Journal of Dermatological Science” This study found that activating Wnt/beta-catenin signaling in hair follicles is sufficient to induce adipocyte generation in the dermis, affecting both hair follicle stem cell activation and adipocyte differentiation.
September 2011 in “Clinical Biochemistry” This review discusses the relationship between vitamin K and osteoarthritis, noting that while lower vitamin K levels are associated with increased osteoarthritis, the effects of vitamin K supplementation on the condition remain unclear due to a lack of clinical trials.
March 2026 in “Trends in Sciences” This review suggests that while platelet-rich plasma has the most robust clinical evidence, platelet-rich fibrin and concentrated growth factors are gaining favor due to their ease of use and absence of additives.
January 2025 in “Dialnet (Universidad de la Rioja)” In this multicenter study, adipose-derived stem cell-enriched fat grafting achieved higher satisfaction and better clinical outcomes compared to platelet-rich plasma and hyaluronic acid filler in aesthetic interventions.
15 citations
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February 2021 in “Scientific Reports” This study identified a specific subpopulation of hair follicle stem cells in mice and humans that are essential for long-term hair regeneration, highlighting the potential for regenerative therapy.
17 citations
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February 2019 in “PubMed” This review discusses strategies to regenerate human hair follicles using stem cells and reports no new experimental results; the authors note existing challenges and the potential of hiPSCs for future applications.
418 citations
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September 2012 in “Nature” This study reports the first instance of skin autotomy in mammals, specifically in African spiny mice, and suggests they may possess a greater regenerative capacity than previously understood, possibly offering insights for regenerative medicine.
256 citations
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October 2013 in “Nature Communications” This study demonstrates that bioengineered lacrimal gland germs can successfully develop and restore tear production and ocular surface protection in a mouse model with lacrimal gland dysfunction.
252 citations
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February 2018 in “npj Regenerative Medicine” This review explores recent advances in understanding molecular mechanisms of tissue regeneration in mammals and suggests potential therapeutic targets, but it reports no new clinical results.
176 citations
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April 2011 in “Science” This study found that in a population of hair follicles, regenerative cycling stages are regulated by both intrinsic and extrinsic signals, with WNT/BMP signaling mediating interactions among follicles for adaptability.
165 citations
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October 2013 in “Nature Communications” This study demonstrates that bioengineered salivary gland transplants can fully regenerate gland function, producing saliva and restoring normal swallowing in salivary gland-defective mice, offering potential for xerostomia treatment.
93 citations
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November 2018 in “Carbohydrate Polymers” This study demonstrated that modified montmorillonites combined with bacterial cellulose enhanced antimicrobial, wound healing, and tissue regenerative activities in a burn mice model, suggesting potential as an artificial skin substitute for burn patients.
92 citations
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August 2017 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that newborn mouse skin organoids can robustly grow hair in vivo, while adult organoids require specific interventions to restore their hair-forming ability.
89 citations
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November 2017 in “Journal of Cellular Physiology” This review discusses the role of Wnt/β‐catenin signaling in stem and cancer stem cell maintenance and its involvement in the development and regeneration of various organs, but reports no new experimental results.
84 citations
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January 2018 in “Biomaterials Science” Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.
84 citations
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June 2013 in “Stem Cells Translational Medicine” This review discusses strategies for regenerating cutaneous nerve function in burn patients and highlights the potential role of autologous skin-derived adult stem cells in improving sensory recovery, but reports no new experimental findings.
78 citations
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October 2012 in “Biomaterials” This study found that both human and rat dermal papilla spheroids can induce hair follicle neogenesis, but larger spheroids increase inductivity without significantly affecting hair fiber diameter.