This study developed a bioresponsive hydrogel combining basic fibroblast growth factor and N-acetylcysteine, which significantly improved diabetic wound healing by enhancing re-epithelialization, collagen deposition, hair follicle regeneration, and neovascularization in response to oxidative stress.
January 2024 in “Elsevier eBooks” The authors concluded that increasing regulatory T cells in patients with alopecia areata may improve hair follicle regeneration by reducing autoimmune responses, suggesting a potential new therapeutic approach since current treatments are often ineffective with high relapse rates.
23 citations
,
November 2019 in “International Journal of Molecular Sciences” This study found that adipose-derived stem cells from HIV-infected patients with lipodystrophy associated with HAART demonstrated similar growth and differentiation potential as those from HIV-uninfected patients, suggesting potential for autologous regenerative therapy.
22 citations
,
October 2018 in “Aesthetic Plastic Surgery” This review discusses the latest understanding of androgenetic alopecia, including stem cell niches in hair follicles, and highlights emerging treatments like growth factors and platelet-rich plasma without new clinical findings.
2 citations
,
September 2025 in “Future Journal of Pharmaceutical Sciences” This study reviewed the potential of Lupeol, a natural triterpenoid, in promoting hair growth and reducing inflammation related to alopecia, revealing promising molecular pathways and favorable pharmacokinetics while suggesting further research to validate these findings.
May 2025 in “ACS Pharmacology & Translational Science” In this study, researchers found that proteins derived from stressed mesenchymal stem cells, stimulated using the root extract of Atalantia monophylla, successfully promoted hair growth and activated hair follicle stem cells in a mouse model of androgenetic alopecia through the Wnt and TGF-β pathways.
March 2025 in “Advanced Materials” This study developed a novel hydrogel dressing, QL@MAB, which facilitates accelerated healing of infected diabetic wounds in rats by offering prolonged drug release, water retention, and adaptive drug delivery in response to high glucose levels in the wound environment.
February 2025 in “Clinical Medical Reviews and Reports” In this study, autologous platelet-rich plasma was associated with improved burn wound healing in a 45-year-old male, showing potential as an adjunctive therapy, but broader trials are needed to confirm its effectiveness.
January 2024 in “Advanced Healthcare Materials” In a mouse model of androgenetic alopecia, this study developed a treatment combining a copper-curcumin nanoparticle oleogel with traditional Gua Sha therapy, which augmented hair regeneration more effectively than minoxidil by improving the follicular microenvironment and regulation of inflammatory responses.
October 2023 in “Bioactive Materials” This study developed a novel liposome-based delivery system for Minoxidil and nitric oxide, which showed promising results in promoting hair regrowth in an androgenetic alopecia model by enhancing transdermal absorption, prolonging skin retention, and reducing inflammation.
April 2023 in “Journal of Investigative Dermatology” This study found that adipose stem cell exosome treatment may improve hair growth and scalp rejuvenation, outperforming minoxidil and showing promise in clinical trials for hair loss, including androgenic alopecia.
40 citations
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June 2013 in “Molecular Pharmaceutics” This study demonstrates that transfected epidermal stem cells using a novel 3D transfection system significantly enhanced wound healing and may serve as an effective therapeutic agent and gene delivery method for wound treatment.
10 citations
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April 2023 in “Acta biomaterialia” This study reported that a newly developed bioadhesive and injectable hydrogel dressing, incorporating hyaluronate-gelatin and the antibiotic doxycycline, accelerated burn wound healing and skin regeneration in rats, highlighting its potential for clinical applications in burn injury therapy.
2 citations
,
June 2024 in “Skin Research and Technology” This study found that low-level laser stimulation activates the Wnt signaling pathway, promoting hair follicle stem cell regeneration and accelerating wound healing.
2 citations
,
January 2014 in “Journal of clinical and diagnostic research” This review discusses various hair loss treatments, such as stem cell therapy, laser therapies, and mesotherapy, emphasizing their potential and limitations while highlighting the need for further research to address genetic factors in hair loss.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this clinical study, Prachhanna followed by Guñjā lepa was found to be more effective than PRP therapy with Minoxidil 5% in improving hair regrowth and reducing symptoms in patients with Indralupta (Alopecia Areata), achieving 91.14% overall improvement compared to 74.74% for the alternative treatment.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study observed that Prachhanna followed by Guñjā lepa was more effective than Platelet-Rich Plasma therapy with Minoxidil 5% in promoting hair regrowth and reducing symptoms of Indralupta, showing greater reductions in hair loss and itching over a 45-day period.
July 2025 in “Materials Today Bio” This study suggests that curcumin-loaded nanoparticles, which activate autophagy and reduce oxidative stress, showed promise in promoting hair growth in an androgenetic alopecia mouse model.
July 2026 in “Journal of Pharmacy and Pharmacology” In this study, gelatin methacrylate hydrogel dressings co-loaded with resveratrol, 18-β-glycyrrhetinic acid, and berberine showed enhanced capabilities in wound closure, infection clearance, and skin structure regeneration in mice with infected wounds compared to dressings with single agents.
19 citations
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April 2015 in “Developmental Dynamics” This study reports that dynamic interactions between stem cells and their niche, influenced by macro-environmental factors, regulate regenerative behavior in integument pattern formation.
24 citations
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May 2010 in “Veterinary dermatology” This study found that both ciclosporin A and topical therapy were effective in reducing alopecia and scaling in dogs with idiopathic sebaceous adenitis, with evidence suggesting improved outcomes when both treatments are combined.
13 citations
,
January 2015 in “Stem cells international” This article reviews the complex roles and therapeutic potential of Mesenchymal Stem Cells across various medical applications, emphasizing their anti-inflammatory and tissue repair functions rather than cell replacement or differentiation, and concludes that more precise measurement of their survival and effectiveness is needed.
10 citations
,
July 2011 in “Wound Repair and Regeneration” This article proposes several potential approaches for scar prevention and therapy, including anti-transforming growth factor-β strategies and tissue-engineered skin, but reports no new clinical results.
5 citations
,
August 2021 in “Clinics in dermatology” This review examines the use of platelet-rich plasma in aesthetic medicine and reports no new clinical results, highlighting the need for further research into its efficacy and safety.
September 2025 in “International Journal of Innovative Technologies in Social Science” This article reviews the versatile applications of red and infrared light therapy, reporting that these treatments can enhance skin health by modulating cellular processes such as RNA and protein synthesis, oxygen consumption, and reducing oxidative stress and inflammation.
55 citations
,
March 2012 in “Journal of Investigative Dermatology” Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.
396 citations
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May 2011 in “Cell stem cell” This study found that Shh from neurons signals to Gli1-expressing cells in the hair follicle, cultivating a niche where these bulge cells can potentially transform into epidermal stem cells in wound healing.
178 citations
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August 2016 in “Advances in wound care” This article discusses advancements in understanding how skin stem cells and fibroblasts contribute to scar formation, highlighting current and potential therapies aimed at preventing or reducing scarring, yet notes that effective treatments without significant side effects are still lacking.
143 citations
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September 2008 in “Experimental gerontology” This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
116 citations
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August 2010 in “Nature” Scientists turned rat thymus cells into stem cells that can help repair skin and hair.