Adipose Stem Cell Exosome: Next Generation Regenerative Aesthetics and Therapeutics for Scalp and Hair

April 2023 in “ Journal of Investigative Dermatology ”

B. Cho

Adipose Stem Cell-derived Exosomes ASCE microneedling dermal papilla cells UVB irradiation minoxidil androgenic alopecia alopecia areata scalp rejuvenation hair regeneration anti-inflammation stem cell exosomes UVB Rogaine hair loss hair growth

TLDR Adipose Stem Cell-derived Exosomes (ASCE) could potentially be used for hair loss treatment and scalp rejuvenation, as they have shown to increase hair length, thickness, and count, and improve conditions like androgenic alopecia and alopecia areata.

Adipose Stem Cell-derived Exosomes (ASCE) are being explored as a potential cell-free therapy for hair loss and scalp rejuvenation. These nano-sized vesicles have been tested in vitro, in vivo, and in clinical studies. In a clinical study involving 29 subjects, a microneedling procedure with topical ASCE treatment was applied for 6 months. The results showed that ASCE could reduce cellular aging of human dermal papilla cells from UVB irradiation and effectively increase the length and thickness of human hairs, outperforming minoxidil. The study also showed an increase of 9 more hair counts per 1cm2, from a baseline of 180 to 189 after 6 months of 10 sessions. ASCE showed strong improvement in cases of androgenic alopecia and alopecia areata, suggesting it could be a next-generation technology for scalp and hair regeneration and anti-inflammation.

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