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research Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth
This study suggests that synthetic ceramides may promote hair growth by inducing proliferation of human dermal papilla cells through modulation of Wnt/β-catenin and BMP2/4 signaling pathways.
research Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells
This laboratory study found that nonanal, a plant scent compound, may stimulate growth factors and cell proliferation in human hair follicle dermal papilla cells, suggesting a cAMP-mediated mechanism.
research Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway
This study found that cepharanthine can inhibit gastric cancer cell activity by inducing oxidative stress and altering energy metabolism, suggesting its potential for gastric cancer treatment.
research Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors
This study found that specific steroids, particularly 5 and 7b, decreased growth of prostate and seminal vesicles and bound to the androgen receptor, showing comparable pharmacological activity to finasteride.
research Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors
This study reported that newly synthesized progesterone derivatives significantly reduced prostate weight in testosterone-treated hamsters, with 5alpha-reductase inhibitory activity dependent on the size of the substituent at C-17.
research Sesamin alleviates androgenetic alopecia by targeting the AR MAPK Wnt axis
In this study, researchers found that sesamin, a component of sesamum, modulated the AR-MAPK-Wnt signaling pathway in DHT-stimulated HaCaT keratinocytes, demonstrating potential multi-target activity against molecular events in androgenetic alopecia.
research Latanoprost-Loaded Nanotransfersomes Designed for Scalp Administration Enhance Keratinocytes Proliferation
This study found that encapsulating latanoprost in nanotransfersomes increased skin penetration and improved its cell proliferation effect in vitro, suggesting potential for treating hair growth disorders.
research THE EFFECT OF TOPICALLY APPLIED γ‐ORYZANOL ON SEBACEOUS GLANDS
This study found that topical γ‐Oryzanol significantly stimulated sebaceous gland cell activity and sebum production in rats.
research Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells
This review highlights the therapeutic potential of hair follicle stem cells in tissue repair and hair regeneration, discussing the molecular mechanisms and the impact of natural compounds on stem cell properties, which may support the development of novel hair loss treatments.
research Safety and compatibility of a new nourishing baby shampoo and tip to toe wash with stearic acid
The new baby shampoo and wash with stearic acid is safe and potentially effective for nourishing babies' skin.
research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system
In a cell-free test setting, this study found that a novel saw palmetto extract effectively inhibited the 5α-reductase type II enzyme, showing promising bioactivity comparable to finasteride for promoting prostate health.
research 1503 Prostaglandin E2 prevents radiotherapy-induced alopecia by attenuating transit amplifying cell apoptosis through promoting G1 arrest
This study found that local PGE2 injection may prevent radiotherapy-induced hair loss by protecting hair follicle cells and promoting hair follicle self-repair.
research Docosahexaenoic acid-acylated astaxanthin esters alleviate cisplatin- induced acute kidney injury by modulating the ferroptosis-related GPX4/xCT signaling pathway and reducing oxidative stress
This research examined krill oil's effects on benign prostatic hyperplasia and found that it inhibited the growth of prostate cells in vitro and reduced prostate size and weight in a BPH rat model, suggesting potential as a prophylactic or therapeutic agent for BPH.
research 有效成分으로 접근해본 두피노화방지(Scalp Anti-Ageing)와 탈모방지(Anti-Hair loss)
This article reviews the potential benefits of GHK-Cu, EAA, and water-soluble propolis for wound healing, skin tightening, and anti-aging effects, but reports no new clinical results.
research A new strategy to modulate alopecia using a combination of two specific and unique ingredients.
In this randomized, placebo-controlled study, the tested cosmetic ingredient containing Trifolium pratense flower extract and a biomimetic peptide increased anagen hair and improved the anagen/telogen ratio over four months in individuals with recessing hair.
research Plants based rich sources of polyunsaturated fatty acids: A comprehensive review
This review discusses PUFA-rich oil seeds and microencapsulation techniques but reports no new clinical results; the authors highlight microencapsulation as a promising method to protect PUFAs from oxidation.
research Effects of biomaterials derived from germinated hemp seeds for stressed hair stem cells and immune cells
This study found that germinated hemp seeds extract and exosomes from their calli can prevent androgenetic alopecia by modulating genetic, cellular, and immune responses in hair follicle dermal papilla stem cells and CD8+ T cells, with exosomes being more effective.
research Topical Prostaglandin Analogues in Androgenetic Alopecia: A Systematic Review of Clinical Evidence
This review concluded that while topical prostaglandin analogues show some potential in treating androgenetic alopecia, evidence is still limited and no products have regulatory approval.
research Latanoprost
A woman got a scalp condition from using latanoprost, but it improved after stopping the drug and starting other treatments.
research Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A
In this study, in silico analysis identified Saponin Re and Emodin as promising candidates for topical treatment of androgenetic alopecia, with Biochanin A having the most favorable safety profile among the tested compounds.
research 52790 Estetrol (E4) prolongs anagen ex vivo: Does E4 have the potential as novel strategy to treat female pattern hair loss?
This study found that estetrol (E4) significantly prolonged the anagen phase and increased hair matrix keratinocyte proliferation in cultured human hair follicles, suggesting its potential as a treatment for female pattern hair loss.
research Development and Evaluation of a Novel Delivery System Containing Phytophospholipid Complex for Skin Aging
This study reports that a newly developed polyherbal phospholipid complex cream containing Citrus auranticum and Glycyrrhiza glabra extracts improved polyphenol retention in the skin, suggesting potential as an anti-aging cosmeceutical.
research Schizochytrium sp. Extracted Lipids Prevent Alopecia by Enhancing Antioxidation and Inhibiting Ferroptosis of Dermal Papilla Cells
This study found that lipids extracted from Schizochytrium sp. significantly enhanced the proliferation and survival of dermal papilla cells under oxidative stress, reduced reactive oxygen species, inhibited ferroptosis, and promoted antioxidant genes, which improved hair growth in experimental settings, suggesting a potential treatment for alopecia.
research Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss
This study found that topical application of TSG from Polygonum multiflorum promoted hair regrowth in depilated mice, potentially through the inhibition of apoptosis-related proteins.
research Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone
This study found that sulforaphane treatment enhanced hair regeneration in ob/ob mice by increasing DHT-degrading enzyme levels and lowering plasma testosterone and DHT.
research Interconnected PolymerS TeChnology (IPSTiC): An Effective Approach for the Modulation of 5α-Reductase Activity in Hair Loss Conditions
This study evaluated a new anti-baldness product, IPSTiC patch hair, designed to treat androgenetic alopecia, and reported that it effectively inhibits NO radical and 5α-reductase activity while maintaining safety and stability, suggesting its potential for topical use.
research Bimatoprost
research Evaluation of the efficacy and toxicity of oral and topical pumpkin oil on the hair growth of mice
This study found that oral pumpkin seed oil increased hair follicle proliferation in mice without causing liver toxicity, unlike finasteride and minoxidil which showed adverse effects.
research Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review
This review found that oral and topical phosphodiesterase inhibitors and topical prostaglandin analogues are safe and effective treatments for various skin diseases, including psoriasis, atopic dermatitis, vitiligo, and alopecia.