Evaluation of the Efficacy and Toxicity of Oral and Topical Pumpkin Oil on the Hair Growth of Mice

    April 2022 in “ Acta histochemica ”
    Greice Klein da Cruz, Maria Manuela Ferreira Pereira da Silva Martins, Flavia Tasmin Techera Antunes … Lucimar Filot da Silva Brum
    Studysummary This study found that oral pumpkin seed oil increased hair follicle proliferation in mice without causing liver toxicity, unlike finasteride and minoxidil which showed adverse effects.
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    Research cited in this study 18

    1. Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles, and Dermal Papilla Cells Clinical, Cosmetic and Investigational Dermatology · 2021
    2. Pharmacological Management of Pattern Hair Loss Indian Journal of Plastic Surgery · 2021
    3. Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia JAMA Dermatology · 2021
    4. Risk of Depression Associated with Finasteride Treatment Journal of Clinical Psychopharmacology · 2021
    5. Pumpkin Seed Oil vs. Minoxidil 5% Topical Foam for the Treatment of Female Pattern Hair Loss: A Randomized Comparative Trial Journal of Cosmetic Dermatology · 2021
    6. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    7. HRQoL in Hair Loss-Affected Patients with Alopecia Areata, Androgenetic Alopecia, and Telogen Effluvium: The Role of Personality Traits and Psychosocial Anxiety Journal of The European Academy of Dermatology and Venereology · 2018
    8. A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle Journal of Molecular Cell Biology · 2018
    9. Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle Biological Reviews · 2014
    10. Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior Cold Spring Harbor Perspectives in Medicine · 2014
    11. Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial Evidence-based Complementary and Alternative Medicine · 2014
    12. Hair Cycle Control by Leptin as a New Anagen Inducer Experimental Dermatology · 2013
    13. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    14. Hair Growth Promoting Effect of Zizyphus Jujuba Essential Oil Food and Chemical Toxicology · 2010
    15. Analyses of Regenerative Wave Patterns in Adult Hair Follicle Populations Reveal Macro-Environmental Regulation of Stem Cell Activity ˜The œInternational journal of developmental biology · 2009
    16. Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents Journal of Investigative Dermatology · 2007
    17. A Study on the Effect of the Leaf Essential Oil of Ocimum Gratissimum Linn. on Cyclophosphamide-Induced Hair Loss International Journal of aromatherapy/International journal of aromatherapy · 2004
    18. Nongenotoxicity of Minoxidil in Murine Hair Follicles as Determined by the Nuclear Aberration Assay Toxicology and Applied Pharmacology · 1988

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    1. Evaluation of the Efficacy and Toxicity of Oral and Topical Pumpkin Oil on the Hair Growth of Mice Acta histochemica · 2022