January 2025 in “International Journal for Research Trends and Innovation” This study assessed a herbal hair oil made from various plant ingredients, observing it supported hair growth and maintained stability for 45 days, with the phytochemical profile indicating the presence of saponins, sulfur, and ascorbic acid.
3 citations
,
January 2023 in “Nutrients” This study found that Hordenine promotes hair regrowth and enhances dermal-papilla cell activity in mice by activating the Wnt/β-catenin signaling pathway, suggesting potential for treating alopecia.
May 2012 in “Scientific American” Blocking a compound called prostaglandin D₂ might help treat hair loss.
July 2024 in “International Journal of Molecular Sciences” In this study, Nigella sativa oil was found to promote dermal papilla cell proliferation and may reduce oxidative stress, suggesting its potential as a hair loss intervention.
5 citations
,
March 2023 in “Journal of Cosmetic Dermatology” This study reports that Plantago asiatica L. extract may promote hair growth by enhancing growth factor production and activating specific signaling pathways in hair follicle dermal papilla cells.
1 citations
,
December 2011 in “Arzneimittelforschung” This study found that the compound 9,11-dehydrocortexolone 17alpha-butyrate (CB-03-04) showed strong local antiandrogenic activity in animal models, suggesting potential for treating prostate conditions.
December 2021 in “Daehanhanuihakoeji” This study suggests that combining finasteride with traditional herbal formulas Yongdamsagan-tang or Paljung-san may not interfere with drug metabolism while potentially enhancing anti-inflammatory effects for treating benign prostatic hyperplasia.
47 citations
,
April 2017 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that dutasteride-loaded nanostructured lipid carriers coated with a stearic acid-chitosan oligomer are stable, less cytotoxic, and suitable for topical delivery to promote hair growth.
19 citations
,
April 2020 in “Journal of ethnopharmacology” This study found that nut oil from Prunus mira promoted hair growth in mice, potentially through the Wnt/β-catenin signaling pathway.
1 citations
,
January 2009 in “X-ray Structure Analysis Online” A new compound was made that might help treat diseases related to male hormones.
65 citations
,
April 2007 in “Chemistry and Physics of Lipids” This study found that incorporating steroid hormones into DPPC liposomes altered their physicochemical properties, including size, zeta potential, and phase transition temperatures.
254 citations
,
March 2023 in “Advanced Science” This study developed an all-natural hydrogel that promotes diabetic wound healing by converting pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophages in a simple and biosafe manner.
This study found that the Padina arborescens extract and its component MOGG may prevent hair loss by inhibiting 5α-reductase activity, promoting cell proliferation, opening the KATP channel, and increasing PGE2 production in laboratory settings.
20 citations
,
March 2005 in “Current Medicinal Chemistry” This study reports that newly synthesized steroidal trienones exhibit higher 5α-reductase inhibitory activity than dienones in various biological models, suggesting potential use in treating androgen-dependent diseases.
March 2026 in “Food Science & Nutrition” In this study, high-dose Arachis hypogaea root extract significantly reduced prostate weight and markers of glandular hyperplasia in testosterone-induced BPH in mice, with associated changes in inflammatory gene expression and beneficial shifts in gut microbiota.
April 2006 in “Dermatologic Clinics” This study found that white wax and its extract significantly promoted hair growth in a mouse model of androgenetic alopecia, outperforming finasteride by inhibiting 5α-reductase activity and enhancing cellular proliferation.
1 citations
,
December 2014 in “International Journal of Pharmacy and Pharmaceutical Sciences” The study observed that Carthamus tinctorius extract-loaded lipid carriers promoted hair growth in C57BL/6 mice more effectively than minoxidil, although further research on humans is needed for confirmation.
7 citations
,
January 2016 in “PubMed” This study found that Delphinium staphisagria seed extracts promoted hair growth in-vitro by increasing human keratinocyte proliferation and inducing angiogenesis without causing overt cytotoxicity.
2 citations
,
August 2020 in “Natural Product Communications” This study found that the topical application of a mixture of Platycladus orientalis leaf extract and α-terpineol promoted hair growth in mice by inducing early anagen transition and increasing growth factor expressions.
10 citations
,
August 1998 in “Journal of Investigative Dermatology” This study observed that the compound EM-402 reduced 5α-reductase activity and sebaceous gland size in the flank organs and ears of hamsters, indicating potent localized anti-androgenic effects without systemic action.
February 2022 in “Research Square (Research Square)” In this cell-based study, researchers found that certain nutraceuticals combined with tamoxifen may influence estrogen receptor expression, potentially offering a protective effect and promoting hair growth during breast cancer therapy.
October 2017 in “Doctoral thesis, UCL (University College London).” This study developed and tested nanostructured lipid carriers for topical dutasteride delivery, finding them stable, low in cytotoxicity and non-irritating, with no drug permeation through pig ear skin over 48 hours.
September 2017 in “Journal of Investigative Dermatology” Ceramide may help delay hair aging by restoring stressed hair cells.
14 citations
,
May 2020 in “Biomolecules & Therapeutics” This study found that vanillic acid from wheat bran promoted dermal papilla cell proliferation, potentially stimulating hair growth by activating the PI3K/Akt and Wnt/β-catenin pathways.
8 citations
,
September 2021 in “EMBO Molecular Medicine” This study found that a 5-mer peptide called P5 promotes hair growth by activating adiponectin receptor 1, suggesting its potential use as a topical treatment for alopecia.
1 citations
,
August 2025 in “Molecules” This review synthesizes research on hederagenin's anticancer and anti-inflammatory potential, emphasizing chemical modifications to enhance its bioactivity, but reports no new experimental findings.
May 2026 in “Journal of Medicinal Food” This study found that orally administered hydrolyzed keratin peptide promoted hair growth and enhanced cellular proliferation and antioxidant capacity in mice and human cell models, suggesting its potential as a functional food ingredient for hair health.
4 citations
,
January 2017 in “Biological & pharmaceutical bulletin” This study found that inhibiting arachidonate 12-lipoxygenase (ALOX12) may enhance hair cuticle maturation by increasing S100A3 protein citrullination and promoting cuticular differentiation in isolated human hair follicles.
18 citations
,
February 2018 in “International Journal of Molecular Sciences” This study found that prostaglandin D2 promotes androgen receptor and AKT signaling in human dermal papilla cells through the DP2 receptor, potentially contributing to androgenetic alopecia.
January 2025 in “Reactions Weekly”